916576-33-5Relevant articles and documents
Efficient palladium(II) catalysis under air. Base-free oxidative heck reactions at room temperature or with microwave heating
Lindh, Jonas,Enquist, Per-Anders,Pilotti, Ake,Nilsson, Peter,Larhed, Mats
, p. 7957 - 7962 (2007)
(Figure Presented) Scope and limitations of the base-free oxidative Heck reaction with arylboronic acids have been explored. Under our conditions, the dmphen-palladium(II)-catalyzed arylation proceeded with air or p-benzoquinone as reoxidants of palladium(0). We found that ambient temperature and mild aerobic conditions allow for the use of substrates sensitive to palladium(II)-catalyzed oxidation. Oxidative Heck couplings, employing different arylboronic acids, were smoothly and regioselectively conducted with both electron-rich and electron-poor olefins, providing high yields even with disubstituted butyl methacrylate, sensitive acrolein, and a vinylboronate ester. Controlled microwave processing was used to reduce reaction times from hours to minutes both in small scale and in 50 mmol scale batch processes.
Mass spectrometric screening of enantioselective Diels-Alder reactions
Teichert, Antje,Pfaltz, Andreas
experimental part, p. 3360 - 3362 (2009/02/07)
(Chemical Equation Presented) A rapid cat. scan: Mass spectrometric monitoring of reaction intermediates of the retro-Diels-Alder reaction has allowed the rapid screening of catalysts for enantioselective Diels-Alder reactions (see scheme). Copper catalysts as well as metal-free organocatalysts were tested. A protocol for the simultaneous screening of catalyst mixtures has also been developed, which offers new possibilities for high-throughput catalyst development.