916603-07-1 Usage
Description
N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine, also known as CZC-8004, is a pan-specific kinase inhibitor with a unique chemical structure that features an aminopyrimidine core. N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine has the ability to bind a range of tyrosine kinases, making it a versatile tool in biological research and potential therapeutic applications.
Uses
Used in Enzyme-Interacting Compounds:
N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine is used as a novel enzyme-interacting compound for the development of immobilized broad-spectrum ligands. Its ability to bind multiple tyrosine kinases allows for the creation of affinity chromatography applications, enabling the capture and purification of these enzymes.
Used in Kinase Inhibition:
In the pharmaceutical industry, N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine is used as a pan-specific kinase inhibitor for targeting a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES. Its inhibitory effects on these kinases at low micromolar concentrations make it a promising candidate for the development of therapeutic agents in various diseases where kinase dysregulation plays a role.
Used in Research Applications:
In the field of biological research, N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine serves as a valuable tool for studying the function and regulation of tyrosine kinases. Its ability to bind multiple kinases allows researchers to investigate the complex interactions and signaling pathways involving these enzymes, contributing to a better understanding of their roles in health and disease.
References
1) Klutchko?et al. (1998),?2-Substituted aminopyrido[2,3-d]pyrilidin-7(8H)-ones, structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity; J. Med. Chem.,?41?3276
Check Digit Verification of cas no
The CAS Registry Mumber 916603-07-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,6,6,0 and 3 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 916603-07:
(8*9)+(7*1)+(6*6)+(5*6)+(4*0)+(3*3)+(2*0)+(1*7)=161
161 % 10 = 1
So 916603-07-1 is a valid CAS Registry Number.
916603-07-1Relevant articles and documents
Process for the identification of novel enzyme interacting compounds
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, (2009/10/01)
The present invention relates to methods for the characterization of enzymes or of enzyme-compound complexes, wherein the enzyme is obtained from a protein preparation with the help of at least one broad spectrum ligand immobilized on a solid support and wherein the enzyme is characterized by mass spectrometry. These methods are useful for the screening of non-immobilized compound libraries, selectivity profiling of lead compounds and mechanism of action studies in living cells.
