916974-76-0

Basic information

• Product Name: 2-(N,N-diethylamino)carbonyloxymethyl-1-(4-hydroxy-3,5-dimethoxybenzoyl)-4-triphenylmethylpiperazine
• Synonyms: 2-(N,N-diethylamino)carbonyloxymethyl-1-(4-hydroxy-3,5-dimethoxybenzoyl)-4-triphenylmethylpiperazine
• CAS NO: 916974-76-0
• Molecular Weight: 637.776
• Mol File: 916974-76-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(N,N-diethylamino)carbonyloxymethyl-1-(4-hydroxy-3,5-dimethoxybenzoyl)-4-triphenylmethylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(N,N-diethylamino)carbonyloxymethyl-1-(4-hydroxy-3,5-dimethoxybenzoyl)-4-triphenylmethylpiperazine(916974-76-0)
• EPA Substance Registry System: 2-(N,N-diethylamino)carbonyloxymethyl-1-(4-hydroxy-3,5-dimethoxybenzoyl)-4-triphenylmethylpiperazine(916974-76-0)

Safety Data

• Hazardous Substances Data: 916974-76-0(Hazardous Substances Data)

Upstream product

• 76-83-5 trityl chloride 
• 530-57-4 3,5-dimethoxy-4-hydroxybenzoic acid 
• 253873-18-6 3-(N,N-diethylaminocarbonyloxymethyl)-1-(triphenylmethyl)piperazine 

Downstream Products

• 916974-77-1 1-(4-butoxy-3,5-dimethoxybenzoyl)-2-(N,N-diethylamino)carbonyloxymethyl-4-triphenylmethylpiperazine 
• 916974-78-2 1-(4-butoxy-3,5-dimethoxybenzoyl)-2-(N,N-diethylamino)carbonyloxymethylpiperazine 

Relevant articles and documents

Structure-activity relationships in platelet-activating factor. Part 13: Synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 or pure antiretroviral activity

HIV-1 infection of the brain and PAF neurotoxicity are implicated in AIDS dementia complex. We previously reported that a trisubstituted piperazine derivative is able to diminish both HIV-1 replication in monocyte-derived macrophages and PAF-induced platelet aggregation. We report in this work new compounds obtained by modifying its piperazine substituents. The structure-activity relationship study shows that a better dual activity or even pure antiretroviral compounds can be obtained in this series.