91714-94-2 Usage
Originator
Duract,Wyeth-Ayerst
Uses
Analgesic.
Definition
ChEBI: Amfenac in which the the hydrogen at the 4 position of the benzoyl group is substituted by bromine. It is used for the management of ocular pain and treatment of postoperative inflammation in patients who have undergone cataract extraction. It was withdraw
from the US market in 1998, following concerns over off-label abuse and hepatic failure.
Veterinary Drugs and Treatments
Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) by
virtue of its ability to block prostaglandin synthesis by inhibiting
cyclooxygenase 1 and 2. Bromfenac is indicated for treatment of
postoperative inflammation in patients who have undergone cataract
extraction.
Check Digit Verification of cas no
The CAS Registry Mumber 91714-94-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,1,7,1 and 4 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 91714-94:
(7*9)+(6*1)+(5*7)+(4*1)+(3*4)+(2*9)+(1*4)=142
142 % 10 = 2
So 91714-94-2 is a valid CAS Registry Number.
InChI:InChI=1/C15H12BrNO3/c16-11-6-4-9(5-7-11)15(20)12-3-1-2-10(14(12)17)8-13(18)19/h1-7H,8,17H2,(H,18,19)
91714-94-2Relevant articles and documents
Novel synthesis method of bromfenac sodium
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Paragraph 0073; 0089-0095; 0112; 0128-0134; 0151; 0167-0173, (2021/11/27)
The novel synthesis method is characterized by comprising the following steps: taking o-aminophenylacetic acid as a starting raw material, and performing acylation reaction to obtain the intermediate I. The intermediate I is subjected to a sulfonation reaction to obtain an intermediate II. The intermediate II is reacted with p-bromobenzoyl chloride to give an intermediate III. The intermediate III is hydrolyzed to give bromfenac. The final finished product bromfenac sodium is obtained by reacting bromfenac and sodium hydroxide. The method has the beneficial effects that an indole ring-containing impurity generated due to a synthetic method in the prior art is avoided. The problem of exceeding standard of final finished product pH caused by using phosphoric acid or glacial acetic acid to produce acid salt in the prior art is avoided.
