917507-77-8

Basic information

• Product Name: (2S)-4-oxopyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-(2-trimethylsilylethoxymethoxy) ester
• CAS NO: 917507-77-8
• Molecular Weight: 393.512
• Mol File: 917507-77-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S)-4-oxopyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-(2-trimethylsilylethoxymethoxy) ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-4-oxopyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-(2-trimethylsilylethoxymethoxy) ester(917507-77-8)
• EPA Substance Registry System: (2S)-4-oxopyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-(2-trimethylsilylethoxymethoxy) ester(917507-77-8)

Safety Data

• Hazardous Substances Data: 917507-77-8(Hazardous Substances Data)

Upstream product

• 13504-85-3 (2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 
• 51-35-4 4R-4-hydroxyproline 
• 81396-84-1 (2S,4R)-1-((benzyloxy)carbonyl)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylic acid 
• 501-53-1 benzyl chloroformate 

Relevant articles and documents

Diastereoselective synthesis of (2S,5S)- and (2S,5R)-N-benzyloxycarbonyl-5-hydroxypipecolic acids from trans-4-hydroxy-l-proline

An efficient diastereoselective synthesis of cis- and trans-5-hydroxy-(2S)-N-benzyloxycarbonyl pipecolic acids, starting from trans-4-hydroxy-l-proline is described. The key synthetic strategies involve the regioisomeric ring expansion of keto ester 8 and diastereoselective reduction of ketone 11 in high selectivity and yield.