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917567-08-9

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917567-08-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 917567-08-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,7,5,6 and 7 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 917567-08:
(8*9)+(7*1)+(6*7)+(5*5)+(4*6)+(3*7)+(2*0)+(1*8)=199
199 % 10 = 9
So 917567-08-9 is a valid CAS Registry Number.

917567-08-9Relevant articles and documents

Synthesis of Benzene and Pyridine 2′-C-Methyl-C-ribonucleosides and -nucleotides

Tokarenko, Anna,Po?tová Slavětínská, Lenka,Klepetá?ová, Blanka,Hocek, Michal

, p. 7962 - 7983 (2015)

A general and modular synthesis of substituted benzene and pyridine 2′-C-methyl-C-ribonucleosides was developed. Benzyl-protected haloaryl-C-nucleoside intermediates were prepared by the addition of bromo(het)aryllithium reagents to a protected lactone, followed by acetylation and reduction. These halogenated intermediates were further transformed by Pd-catalysed cross-couplings, aminations, or hydroxylations. The final deprotection was rather troublesome, and different procedures involving catalytic hydrogenation on Pd/C, or treatment with BCl3, were optimized for each derivative. The final C-nucleosides were also all converted into the corresponding NTPs. None of the C-nucleosides showed any activity in the HCV replicon assay, and none of the NTPs showed any significant inhibition of the HCV polymerase. C-Nucleoside carba-analogues of clinically used antiviral 2′-C-methylribonucleosides were designed and synthesized, but were found to be inactive.

CD73 INHIBITORS

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Paragraph 196, (2020/10/27)

Disclosed are compounds that are inhibitors of CD73 and are useful in treating CD73-associated diseases or conditions, and compositions containing the compounds.

METHODS FOR TREATING HCV

-

, (2013/03/28)

This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.

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