917805-74-4

Basic information

• Product Name: (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid-2-methylpropan-2-amine
• Synonyms: (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid-2-methylpropan-2-amine
• CAS NO: 917805-74-4
• Molecular Weight: 554.683
• Mol File: 917805-74-4.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid-2-methylpropan-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid-2-methylpropan-2-amine(917805-74-4)
• EPA Substance Registry System: (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid-2-methylpropan-2-amine(917805-74-4)

Safety Data

• Hazardous Substances Data: 917805-74-4(Hazardous Substances Data)

Usage

Description

(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid-2-methylpropan-2-amine is a complex organic molecule characterized by the presence of a pyrimidine ring, a fluorophenyl group, a methylsulfonyl group, and a 3,5-dihydroxyhept-6-enoic acid chain. Additionally, it features a 2-methylpropan-2-amine side chain. (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid-2-methylpropan-2-amine's multiple functional groups and stereochemistry contribute to its intricate structure, making it a challenging molecule to synthesize and study. Due to its unique features, it may possess potential biological activity and could be explored for applications in pharmaceutical research or drug development.

Uses

Used in Pharmaceutical Research:
(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid-2-methylpropan-2-amine is used as a compound of interest in pharmaceutical research for its potential biological activity. The presence of various functional groups and its complex structure suggest that it may interact with biological targets in ways that could lead to the development of new therapeutic agents.
Used in Drug Development:
In the field of drug development, (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid-2-methylpropan-2-amine may be utilized as a lead compound. Its unique structural features could be optimized to enhance its pharmacological properties, such as potency, selectivity, and bioavailability, making it a candidate for further investigation and potential clinical applications.

Upstream product

• 75-64-9 tert-butylamine 
• 124752-23-4 tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate 
• 956034-92-7 N-{4-(4-fluorophenyl)-6-isopropyl-5-[(1-methyl-1H-benzo[d]imidazol-2-ylsulfonyl)methyl]pyrimidin-2-yl}-N-methylmethanesulfonamide 
• 355806-00-7 rosuvastatin tert-butyl ester 
• 1019874-87-3 C₃₁H₄₅FN₄O₅S 
• 1019876-66-4 (+)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl)-(3R,5S,6E)-dihydroxy-hept-6-enoic acid n-butylamide 
• 287714-41-4 rosuvastatin 
• 1337534-50-5 tert-butyl 2-(6-{[5-(difluoromethoxy)-1-methyl-1H-1,3-benzodiazole-2-sulfonyl]methyl}-2,2-dimethyl-1,3-dioxan-4-yl)acetate 
• 147118-37-4 N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide 
• 147118-40-9 (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid methyl ester 
• 851443-04-4 ethyl (3R),(5S),(6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxy-6-heptenoate 
• 147118-39-6 methyl (3R,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3-hydroxy-5-oxohept-6-enoate 
• 1364244-21-2 5-O-(triphenylmethyl)-3-deoxy-2-O-(methanesulfonyl)-D-glyceropent-2-enono-1,4-lactone 
• 1364244-19-8 5-O-(triphenylmethyl)-D-arabinono-1,4-lactone 

Downstream Products

• 287714-41-4 rosuvastatin 

Relevant articles and documents

Method for the preparation of high purity Rosuvastatin Calcium salt

The present invention relates to a method for manufacturing a Rosuvastatin calcium salt by using a Rosuvastatin tert-butyl amine salt, and to a method for manufacturing a high purity Rosuvastatin calcium salt, which has impurities less than 0.1% of a diastereomer. The manufacturing method of a high purity Rosuvastatin calcium salt comprises the steps of: 1) manufacturing a compound represented by chemical formula III by reducing a compound represented by chemical formula IV; 2) manufacturing a compound represented by chemical formula II by adding t-butyl amine; and 3) manufacturing a compound represented by chemical formula I by adding a calcium ion to the compound represented by chemical formula II.COPYRIGHT KIPO 2016

AMINE SALTS OF PITAVASTATIN AND ROSUVASTATIN

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NOVEL INTERMEDIATES FOR THE PREPARATION OF HMG-CoA REDUCTASE INHIBITORS

The present invention provides a process for preparing novel intermediates of Formula wherein, R1 can be hydrogen, C1-C4 alkyl, halogen, nitro, hydroxy, or C1-C4 alkoxy; Rx can be selected from hydrophobic residue of HMG-CoA reductase inhibitors; which can be effectively used for the preparation of HMG-CoA reductase inhibitors such as rosuvastatin and pharmaceutically acceptable salts thereof.