917952-93-3Relevant articles and documents
Iron catalyzed efficient synthesis of poly-functional primary amines via the direct use of ammonia
Ma, Chaoqun,Chen, Jianghui,Xing, Dong,Sheng, Yuan,Hu, Wenhao
supporting information, p. 2854 - 2857 (2017/03/11)
An iron catalyzed three-component reaction of alkyl diazoesters, isatins and ammonia is reported. This reaction provided convenient access to non-protected β-hydroxy-α-aminoesters with adjacent quaternary stereocenters. This transformation is achieved via trapping of ammonium ylide which is generated from a diazocompound and ammonia under mild reaction conditions. Poly-functional group unprotected amines are obtained exclusively with up to 77% yield and 62?:?38 dr.
