918-05-8Relevant articles and documents
Paquette,Rosen
, p. 311,312 (1966)
Aryldiazonium bis(trifluoromethyl)imides
Hirschberg,Ignat'Ev,Wenda,Frohn,Willner
experimental part, p. 183 - 186 (2012/04/10)
Aryldiazonium bis(trifluoromethyl)imides, [ArN2][N(CF 3)2], are the first examples of diazonium salts with this type of anion. Their syntheses and properties will be presented and compared to aryldiazonium bis(trifluoromethylsulfonyl)imides. [ArN2][N(CF 3)2] are less stable diazonium salts in comparison to [ArN2][N(SO2CF3)2] due to the higher nucleophilicity of the [N(CF3)2]- anion.
Hepatoselectivity of statins: Design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors
Park, William K.C.,Kennedy, Robert M.,Larsen, Scott D.,Miller, Steve,Roth, Bruce D.,Song, Yuntao,Steinbaugh, Bruce A.,Sun, Kevin,Tait, Bradley D.,Kowala, Mark C.,Trivedi, Bharat K.,Auerbach, Bruce,Askew, Valerie,Dillon, Lisa,Hanselman, Jeffrey C.,Lin, Zhiwu,Lu, Gina H.,Robertson, Andrew,Sekerke, Catherine
, p. 1151 - 1156 (2008/09/19)
4-Sulfamoyl pyrroles were designed as novel hepatoselective HMG-CoA reductase inhibitors (statins) to reduce myalgia, a statin-induced adverse effect. The compounds were prepared via a [3 + 2] cycloaddition of a Muenchnone with a sulfonamide-substituted alkyne. We identified compounds with greater selectivity for hepatocytes compared to L6-myocytes than rosuvastatin and atorvastatin. There was an inverse correlation of myocyte potencies and C log P values. A number of analogs were effective at reducing cholesterol in acute and chronic in vivo models but they lacked sufficient chronic in vivo activity to warrant further development.