91813-36-4

Basic information

• Product Name: Thiazolo[5,4-b]pyridine, 2-phenyl-
• CAS NO: 91813-36-4
• Molecular Formula: C12H8N2S
• Molecular Weight: 212.275
• Mol File: 91813-36-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Thiazolo[5,4-b]pyridine, 2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiazolo[5,4-b]pyridine, 2-phenyl-(91813-36-4)
• EPA Substance Registry System: Thiazolo[5,4-b]pyridine, 2-phenyl-(91813-36-4)

Safety Data

• Hazardous Substances Data: 91813-36-4(Hazardous Substances Data)

Upstream product

• 57135-09-8 1H,2H-[1,3]thiazolo[5,4-b]pyridine-2-thione 
• 603-33-8 triphenylbismuthane 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 2227-79-4 benzenecarbothioamide 
• 5221-40-9 N-(3-pyridinyl)benzamide 
• 91813-32-0 N-(2-chloro-3-pyridinyl)phenylamide 
• 59171-46-9 N-(3-pyridinyl)phenylthioamide 
• 936-61-8 Thiobenzoic acid O-ethyl ester 
• 6298-19-7 2-chloro-3-aminopyridine 

Downstream Products

• 123729-33-9 1-(4-Oxy-2-phenyl-thiazolo[5,4-b]pyridin-5-yl)-ethanol 
• 123729-24-8 1-(2-Phenyl-thiazolo[5,4-b]pyridin-7-yl)-ethanol 
• 123729-31-7 C₁₂H₇LiN₂OS 
• 123729-22-6 C₁₂H₇LiN₂S 
• 123729-29-3 2-Phenyl-thiazolo[5,4-b]pyridine 4-oxide 

Relevant articles and documents

Liebeskind-Srogl-type cross-coupling reaction of azole-2-thiones with triarylbismuthines: Synthesis of 2-arylazoles

Liebeskind-Srogl-type C(HetAr)–C(Ar) bond formation using trivalent organobismuth compounds as a new class of arylating reagents is described. The reaction of benzazole-2-thiones with triarylbismuthines in the presence of 10 mol% Pd(dba)2 and 2.0 equiv. Cu(OAc)2 at 80 °C affords 2-arylbenzothiazoles, benzoxazoles, and N-methyl benzimidazole in moderate-to-high yield. The reaction is sensitive to the electronic nature of triarylbismuthines: compounds bearing an electron-withdrawing group on the phenyl ring showed higher reactivity than those having an electron-donating group.

Nouvelle methode de synthese de thiazolopyridines

It has been established that the direct condensation between aromatic and aliphatic thioesters and the variously generated anion of aminochloropyridines represents the best method for the synthesis of thiazolopyridines.The transient thioamides, sometimes isolated, can be easily converted chemically or photochemically into the desired fused heterocycles.

2-ARYL-OXAZOLO- AND THIAZOLOPYRIDINES. SYNTHESIS VIA CYCLIZATION OF N-(2-CHLORO-3-PYRIDINYL)ARYLAMIDES AND THIOAMIDES

Chloropyridinylenamides can by easily converted into oxazolo- and thiazolo pyridines by treatment with polyphosphoric acid and Lawesson reagent respectively.