91818-68-7 Usage
General Description
4-Methyl-3-phenylisothiazol-5-amine is a chemical compound distinguished by its organic structural components, namely a phenyl group and an isothiazol group. It contains elements such as carbon, hydrogen, sulfur, and nitrogen. Its molecular composition exhibits two cyclic components, a benzene ring and an isothiazol ring, which effectively characterizes it as a heterocyclic compound. Although the specific applications or properties of this chemical are not extensively known, compounds of this nature are generally valuable in chemical research or industrial process due to their structural complexity and unique chemical characteristics. Before handling, one should familiarize oneself with safety details, storage, and disposal instructions due to its possibly hazardous nature.
Check Digit Verification of cas no
The CAS Registry Mumber 91818-68-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,1,8,1 and 8 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 91818-68:
(7*9)+(6*1)+(5*8)+(4*1)+(3*8)+(2*6)+(1*8)=157
157 % 10 = 7
So 91818-68-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H10N2S/c1-7-9(12-13-10(7)11)8-5-3-2-4-6-8/h2-6H,11H2,1H3
91818-68-7Relevant articles and documents
3-Phenyl-5-isothiazole carboxamides with potent mGluR1 antagonist activity
Fisher, Matthew J.,Backer, Ryan T.,Barth, Vanessa N.,Garbison, Kim E.,Gruber, Joseph M.,Heinz, Beverly A.,Iyengar, Smriti,Hollinshead, Sean P.,Kingston, Anne,Kuklish, Steven L.,Li, Linglin,Nisenbaum, Eric S.,Peters, Steven C.,Phebus, Lee,Simmons, Rosa Maria A.,Van Der Aar, Ellen
, p. 2514 - 2517 (2012/05/05)
The disclosed 3-phenyl-5-isothiazole carboxamides are potent allosteric antagonists of mGluR1 with generally good selectivity relative to the related group 1 receptor mGluR5. Pharmacokinetic properties of a member of this series (1R,2R)-N-(3-(4-methoxyphenyl)-4-methylisothiazol-5-yl)-2- methylcyclopropanecarboxamide (14) are good, showing acceptable plasma and brain exposure after oral dosing. Oral administration of isothiazole 14 gave robust activity in the formalin model of persistent pain which correlated with CNS receptor occupancy.
