918308-66-4

Basic information

• Product Name: tert-butyl (2E)-3-(2-{4-[(4-allylpiperazin-1-yl)methyl]phenyl}-8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate
• Synonyms: tert-butyl (2E)-3-(2-{4-[(4-allylpiperazin-1-yl)methyl]phenyl}-8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate
• CAS NO: 918308-66-4
• Molecular Weight: 668.86
• Mol File: 918308-66-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl (2E)-3-(2-{4-[(4-allylpiperazin-1-yl)methyl]phenyl}-8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (2E)-3-(2-{4-[(4-allylpiperazin-1-yl)methyl]phenyl}-8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate(918308-66-4)
• EPA Substance Registry System: tert-butyl (2E)-3-(2-{4-[(4-allylpiperazin-1-yl)methyl]phenyl}-8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate(918308-66-4)

Safety Data

• Hazardous Substances Data: 918308-66-4(Hazardous Substances Data)

Upstream product

• 918309-29-2 tert-butyl (2E)-3-(2-[4-(bromomethyl)phenyl]-8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate 
• 13961-36-9 1-allylpiperazine 
• 881997-05-3 tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate 
• 918309-14-5 tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-[4-(hydroxymethyl)phenyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate 
• 59016-93-2 p-hydroxymethylphenylboronic acid 

Downstream Products

• 918308-67-5 tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-4-oxo-2-[4-(4-piperazin-1-ylmethyl)phenyl]-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate 
• 918309-35-0 tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-(4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}phenyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate 
• 918309-37-2 tert-butyl (2E)-3-(2-(4-{[4-(2-tert-butoxy-2-oxoethyl)piperazin-1-yl]methyl}phenyl)-8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate 

Relevant articles and documents

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 6: Exploration of aromatic substituents

A series of 4-oxo-4H-pyrido[1,2-a]pyrimidine derivatives, derivatized at the 2-position with aromatic substituents, were synthesized by the Suzuki cross-coupling method and evaluated for their ability to potentiate the activity of the fluoroquinolone levo