918340-51-9

Basic information

• Product Name: 4-chlorofuro[2,3-d]pyrimidine
• Synonyms: 4-chlorofuro[2,3-d]pyrimidine;4-Chlorofuro[2,3-d]pyrimi...;Furo[2,3-d]pyriMidine, 4-chloro-
• CAS NO: 918340-51-9
• Molecular Formula: C₆H₃ClN₂O
• Molecular Weight: 154.55382
• Mol File: 918340-51-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 230.852 °C at 760 mmHg
• Flash Point: 93.416 °C
• Appearance: /
• Density: 1.476 g/cm³
• Vapor Pressure: 0.098mmHg at 25°C
• Refractive Index: 1.634
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-chlorofuro[2,3-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chlorofuro[2,3-d]pyrimidine(918340-51-9)
• EPA Substance Registry System: 4-chlorofuro[2,3-d]pyrimidine(918340-51-9)

Safety Data

• Hazardous Substances Data: 918340-51-9(Hazardous Substances Data)

Usage

General Description

4-chlorofuro[2,3-d]pyrimidine is a chemical compound with the molecular formula C5H3ClN2O. It is a heterocyclic compound that consists of a pyrimidine ring with a chloro substitution at the 4th position and a furo moiety fused at the 2,3 position. 4-chlorofuro[2,3-d]pyrimidine is used in organic synthesis and medicinal chemistry as a building block for the synthesis of various pharmaceuticals and agrochemicals. It is also used as a reagent in the preparation of other chemical compounds. The 4-chlorofuro[2,3-d]pyrimidine is a versatile and important chemical in the field of organic chemistry and has various applications in the pharmaceutical and agrochemical industries.

InChI:InChI=1/C6H3ClN2O/c7-5-4-1-2-10-6(4)9-3-8-5/h1-3H

Upstream product

• 139370-56-2 2-aminofuran-3-carbonitrile 
• 186454-70-6 furo[2,3-d]pyrimidin-4-amine 

Downstream Products

• 1613479-37-0 C₁₂H₆F₂N₂O₂ 
• 918340-57-5 2-chloro-5-(furo[2,3-d]pyrimidin-4-ylamino)-phenol 

Relevant articles and documents

HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS

The present invention provides, in part, compounds of Formula (I) and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1 -associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), schizotypal personality disorder, cognitive impairment (e.g., cognitive impairment associated with schizophrenia, AD, PD, or pharmacotherapy therapy), ADHD, Parkinson's disease, anxiety, and depression.

COMPOUNDS AND METHODS FOR THE TREATMENT OF VIRUSES AND CANCER

The present invention relates to compounds according to the formula I: Where Ra is H or an optionally OH-substituted C1-C3 alkyl; R1 is OR1, an optionally substituted C4-12 carbocyclic group which may be saturated or unsaturated (including aromatic) or an optionally substituted heterocyclic group; R1 is an optionally substituted C1-C14 hydrocarbyl group or an optionally substituted heterocyclic group;; R2 , R3 and R4 are each independently H, an optionally substituted C1-C4 alkyl group (preferably CH3, CH2CH3 or CF3), halogen (preferably F, Cl, Br), OR, CN, NO2, a C1-C6 thioether, a C1-C6 thioester group, an optionally substituted CO2R group, an optionally substituted COR group or an optionally substituted OCOR group (preferably R4 is H); R is H or an optionally substituted C1-C6 alkyl group; RHET is an optionally substituted heterocyclic group; and pharmaceutically acceptable salts, solvates or polymorphs thereof.