918452-16-1

Basic information

• Product Name: 2-Azabicyclo[2.2.1]heptan-3-one, 6-hydroxy-2-[(4-methoxyphenyl)methyl]-, (1S,4R,6S)-
• CAS NO: 918452-16-1
• Molecular Formula: C14H17NO3
• Molecular Weight: 247.294
• Mol File: 918452-16-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Azabicyclo[2.2.1]heptan-3-one, 6-hydroxy-2-[(4-methoxyphenyl)methyl]-, (1S,4R,6S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Azabicyclo[2.2.1]heptan-3-one, 6-hydroxy-2-[(4-methoxyphenyl)methyl]-, (1S,4R,6S)-(918452-16-1)
• EPA Substance Registry System: 2-Azabicyclo[2.2.1]heptan-3-one, 6-hydroxy-2-[(4-methoxyphenyl)methyl]-, (1S,4R,6S)-(918452-16-1)

Safety Data

• Hazardous Substances Data: 918452-16-1(Hazardous Substances Data)

Upstream product

• 105-13-5 4-Methoxybenzyl alcohol 
• 824-94-2 p-methoxybenzyl chloride 
• 130931-83-8 (1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one 
• 169104-33-0 (1S,4R)-2-[(4-methoxyphenyl)methyl]-2-azabicyclo[2.2.1]hept-5-en-3-one 
• 168960-17-6 (1R,4S)-2-(p-Methoxybenzyl)-2-azabicyclo<2.2.1>-5-hepten-3-one 
• 79200-56-9 (-)-2-azabicyclo[2.2.1]hept-5-en-3-one 
• 918452-15-0 C₁₆H₁₉NO₄ 

Downstream Products

• 640897-02-5 (1S,4S)-6-difluoromethylenyl-2-(4‘-methoxybenzyl)-2-azabicyclo[2.2.1]heptan-3-one 
• 918452-25-2 (1S,4R)-6-trifluoromethyl-2-(4-methoxybenzyl)-2-azabicyclo[2.2.1]hept-5-en-3-one 
• 918452-17-2 (1S,4R)-6-iodo-2-(4-methoxybenzyl)-2-azabicyclo[2.2.1]hept-5-en-3-one 
• 918452-26-3 (1S,4R)-6-pentafluoroethyl-2-(4-methoxybenzyl)-2-azabicyclo[2.2.1]hept-5-en-3-one 
• 918452-32-1 (1S,4S)-6-bromomethylene-2-(4-methoxybenzyl)-2-azabicyclo[2.2.1]heptan-3-one 
• 918452-31-0 (1S,4S)-6-bromomethylene-2-(4-methoxybenzyl)-2-azabicyclo[2.2.1]heptan-3-one 
• 918452-33-2 (Z)-(1S,4S)-2-(4-methoxybenzyl)-6-(2,2,2-trifluoroethylidene)-2-azabicyclo[2.2.1]heptan-3-one 
• 918452-34-3 (E)-(1S,4S)-2-(4-methoxybenzyl)-6-(2,2,2-trifluoroethylidene)-2-azabicyclo[2.2.1]heptan-3-one 
• 918452-27-4 (1S,4S)-6-dibromomethylene-2-(4-methoxybenzyl)-2-azabicyclo[2.2.1]heptan-3-one 
• 169104-33-0 (1S,4R)-2-[(4-methoxyphenyl)methyl]-2-azabicyclo[2.2.1]hept-5-en-3-one 

Relevant articles and documents

Mechanism-Based Design of 3-Amino-4-Halocyclopentenecarboxylic Acids as Inactivators of GABA Aminotransferase

Aminotransferases are pyridoxal 5′-phosphate-dependent enzymes that catalyze reversible transamination reactions between an amino acid and an α-keto acid, playing a critical role in cellular nitrogen metabolism. It is evident that γ-aminobutyric acid aminotransferase (GABA-AT), which balances the levels of inhibitory and excitatory neurotransmitters, has emerged as a promising therapeutic target for epilepsy and cocaine addiction based on mechanism-based inactivators (MBIs). In this work, we established an integrated approach using computational simulation, organic synthesis, biochemical evaluation, and mass spectrometry to facilitate our design and mechanistic studies of MBIs, which led to the identification of a new cyclopentene-based analogue (6a), 25-times more efficient as an inactivator of GABA-AT compared to the parent compound (1R,3S,4S)-3-amino-4-fluorocyclopentane carboxylic acid (FCP, 4).

Unexpected Retroaldol-Aldol Reaction during O-Alkylation of Hydroxylated Vince Lactam Derivatives

The unexpected retroaldol-aldol reaction during O-alkylation of a β-hydroxy lactam was found to be highly dependent on the temperature and shows a remarkable solvent effect. In DMF, O-alkylation is faster than retroaldol-aldol rearrangement giving exclusively products with retention of configuration. In THF, O-alkylation is slower than rearrangement, giving selectively products with inversion of stereochemistry. In DMSO, a retroaldol reaction followed by fast intramolecular proton transfer occurs to give the ring-opened aldehyde.