918483-35-9

Basic information

• Product Name: 4-iodo-1-(2,2,2-trifluoroethyl)-1H-pyrazole
• Synonyms: 4-iodo-1-(2,2,2-trifluoroethyl)-1H-pyrazole
• CAS NO: 918483-35-9
• Molecular Weight: 276
• Mol File: 918483-35-9.mol

Chemical Properties

• CAS DataBase Reference: 4-iodo-1-(2,2,2-trifluoroethyl)-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-iodo-1-(2,2,2-trifluoroethyl)-1H-pyrazole(918483-35-9)
• EPA Substance Registry System: 4-iodo-1-(2,2,2-trifluoroethyl)-1H-pyrazole(918483-35-9)

Safety Data

• Hazardous Substances Data: 918483-35-9(Hazardous Substances Data)

Usage

Description

4-iodo-1-(2,2,2-trifluoroethyl)-1H-pyrazole is a chemical compound characterized by the presence of an iodine atom at the 4-position and a trifluoroethyl group at the 1-position of the pyrazole ring. This unique structure endows it with specific chemical properties and reactivity, making it a valuable intermediate in the synthesis of various pharmaceutical compounds.

Uses

Used in Pharmaceutical Industry:
4-iodo-1-(2,2,2-trifluoroethyl)-1H-pyrazole is used as a reactant in the preparation of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1). These inhibitors play a crucial role in the development of targeted therapies for the treatment of cancer, as they can disrupt the normal cell division process and lead to the inhibition of tumor growth.
In the synthesis of MPS1 inhibitors, 4-iodo-1-(2,2,2-trifluoroethyl)-1H-pyrazole serves as a key building block, providing the necessary structural features and reactivity for the formation of the desired 1H-pyrrolo[3,2-c]pyridine scaffold. The trifluoroethyl group imparts lipophilicity and metabolic stability to the final product, while the iodine atom can be further functionalized or serve as a handle for the attachment of other functional groups.
The development of MPS1 inhibitors using 4-iodo-1-(2,2,2-trifluoroethyl)-1H-pyrazole as a reactant has the potential to contribute to the advancement of cancer therapeutics by offering new treatment options with improved efficacy, selectivity, and reduced side effects compared to conventional chemotherapy. Additionally, the versatility of this compound as a synthetic intermediate may also lead to the discovery of other bioactive molecules with diverse applications in the pharmaceutical field.