918523-66-7

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine, 5-methyl-1-[tris(1-methylethyl)silyl]-
• Synonyms: 1H-Pyrrolo[2,3-b]pyridine, 5-methyl-1-[tris(1-methylethyl)silyl]-;(5-methylpyrrolo[2,3-b]pyridin-1-yl)-tri(propan-2-yl)silane
• CAS NO: 918523-66-7
• Molecular Formula: C₁₇H₂₈N₂Si
• Molecular Weight: 288.5
• Mol File: 918523-66-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 321.5°C at 760 mmHg
• Flash Point: 148.3°C
• Appearance: /
• Density: 0.96g/cm³
• Vapor Pressure: 0.000296mmHg at 25°C
• Refractive Index: 1.52
• PKA: 5.52±0.30(Predicted)
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine, 5-methyl-1-[tris(1-methylethyl)silyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine, 5-methyl-1-[tris(1-methylethyl)silyl]-(918523-66-7)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine, 5-methyl-1-[tris(1-methylethyl)silyl]-(918523-66-7)

Safety Data

• Hazardous Substances Data: 918523-66-7(Hazardous Substances Data)

Usage

Molecular Structure

The compound consists of a pyrrolopyridine ring with a six-membered ring containing a nitrogen atom, a methyl group attached to the 5-position of the ring, and a tris(1-methylethyl)silyl group attached to the 1-position of the ring.

Functional Groups

The compound contains a pyrrolopyridine ring, a methyl group, and a tris(1-methylethyl)silyl group.

Reactivity

The tris(1-methylethyl)silyl group acts as a protective group, preventing unwanted side reactions with sensitive functional groups.

Uses

The compound is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of biologically active molecules and pharmaceutical compounds.

Unique Structure

The compound's unique structure and reactivity make it an important tool for synthetic organic chemists in the development of new drugs and materials.

InChI:InChI=1/C17H28N2Si/c1-12(2)20(13(3)4,14(5)6)19-9-8-16-10-15(7)11-18-17(16)19/h8-14H,1-7H3

Upstream product

• 858116-66-2 5-bromo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 1344666-90-5 (6-ethoxy-pyridin-3-yl)-[6-fluoro-5-(5-methyl-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-pyridin-2-yl]-carbamic acid tert-butyl ester 
• 1138443-83-0 3-iodo-5-methyl-1H-pyrrolo[2,3-b]pyridine 
• 824-52-2 5-methyl-1H-pyrrolo[2,3-b]pyridine 
• 1344666-89-2 (6-ethoxy-pyridin-3-yl)-{6-fluoro-5-[hydroxy-(5-methyl-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-methyl]-pyridin-2-yl}-carbamic acid tert-butyl ester 
• 1303426-58-5 {6-fluoro-5-[hydroxy-(5-methyl-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]pyridin-2-yl}-(4-methoxybenzyl)carbamic acid tert-butyl ester 

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