918524-58-0

Basic information

• Product Name: 2-fluoro-5-(propylsulfonamido)benzoic acid
• Synonyms: 2-fluoro-5-(propylsulfonamido)benzoic acid
• CAS NO: 918524-58-0
• Molecular Weight: 261.274
• Mol File: 918524-58-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-fluoro-5-(propylsulfonamido)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-5-(propylsulfonamido)benzoic acid(918524-58-0)
• EPA Substance Registry System: 2-fluoro-5-(propylsulfonamido)benzoic acid(918524-58-0)

Safety Data

• Hazardous Substances Data: 918524-58-0(Hazardous Substances Data)

Upstream product

• 56741-33-4 5-amino-2-fluorobenzoic acid 
• 56741-34-5 methyl 5-amino-2-fluorobenzoate 
• 2965-22-2 methyl 2-fluoro-5-nitro-benzoate 

Downstream Products

• 918524-59-1 2-fluoro-5-(propane-1-sulfonylamino)-benzoic acid methyl ester 

Relevant articles and documents

From off-to on-target: New BRAF-inhibitor-template-derived compounds selectively targeting mitogen activated protein kinase kinase 4 (MKK4)

The mitogen-activated protein kinase (MAP) kinase 4 (MKK4) was found to be a major regulator of liver regeneration and could be a valuable drug target addressing liver related diseases by restoring its intrinsic regenerative capacity. We report on the synthesis and optimization of novel MKK4 inhibitors following a target-hopping strategy from the FDA-approved BRAFV600E inhibitor PLX4032 (8). Applying an iterative multi-parameter optimization process we carved out essential structural features yielding in compounds with a low nanomolar affinity for MKK4 and excellent selectivity profiles against the main off-targets MKK7 and JNK1, which, upon relevant inhibition, would totally abrogate the pro-regenerative effect of MKK4 inhibition, as well as against the off-targets MAP4K5, ZAK and BRAF with selectivity factors ranging from 40 to 430 for our best-balanced compounds 70 and 73.