918525-02-7

Basic information

• Product Name: 3-Bromo-1-[tris(1-methylethyl)silyl]-1H-pyrrolo[2,3-b]pyridine
• Synonyms: 3-Bromo-1-[tris(1-methylethyl)silyl]-1H-pyrrolo[2,3-b]pyridine;3-Bromo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine;3-broMo-1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridine;3-Bromo-1-(triisopropylsilyl)
• CAS NO: 918525-02-7
• Molecular Formula: C16H25BrN2Si
• Molecular Weight: 353.37
• Mol File: 918525-02-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.19
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-Bromo-1-[tris(1-methylethyl)silyl]-1H-pyrrolo[2,3-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-1-[tris(1-methylethyl)silyl]-1H-pyrrolo[2,3-b]pyridine(918525-02-7)
• EPA Substance Registry System: 3-Bromo-1-[tris(1-methylethyl)silyl]-1H-pyrrolo[2,3-b]pyridine(918525-02-7)

Safety Data

• Hazardous Substances Data: 918525-02-7(Hazardous Substances Data)

Usage

General Description

3-Bromo-1-[tris(1-methylethyl)silyl]-1H-pyrrolo[2,3-b]pyridine is a chemical compound with the molecular formula C18H24BrNSi. It is a pyrrolopyridine derivative with a bromine atom and a tris(1-methylethyl)silyl group attached to the pyridine ring. 3-Bromo-1-[tris(1-methylethyl)silyl]-1H-pyrrolo[2,3-b]pyridine is used in organic synthesis as a building block for the preparation of pharmaceuticals, agrochemicals, and functional materials. It has potential applications in the development of new drugs and materials due to its unique structure and reactivity. Additionally, the tris(1-methylethyl)silyl group can serve as a protecting group for sensitive functional groups during chemical reactions. Overall, 3-Bromo-1-[tris(1-methylethyl)silyl]-1H-pyrrolo[2,3-b]pyridine is a versatile compound with numerous potential uses in the field of chemical and pharmaceutical research.

Upstream product

• 74420-15-8 3-bromo-1H-pyrrolo[2,3-b]pyridine 
• 13154-24-0 triisopropylsilyl chloride 

Downstream Products

• 1093759-49-9 1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine 

Relevant articles and documents

A closer look at the bromine-lithium exchange with tert-butyllithium in an aryl sulfonamide synthesis

A practical protocol for the one-pot synthesis of various aryl sulfonamides, notably of pyridine-core-substituted 7-azaindolyl sulfonamides, is described. A key step is the well-known bromine-lithium exchange reaction of an aryl bromide with tert-butyllithium (t-BuLi). Differing from the common practice to use 2 or more equiv of organolithium, the exact amount of t-BuLi needed for a sufficient exchange reaction is determined for each aryl bromide in a GC-MS-assisted experiment.