918659-10-6 Usage
Description
Dehydro Azelnidipine is a derivative of Azelnidipine (A808500), a calcium channel blocker with antihypertensive and anti-atherosclerotic properties.
Uses
Used in Pharmaceutical Industry:
Dehydro Azelnidipine is used as an active pharmaceutical ingredient for the development of antihypertensive medications. It functions by blocking calcium channels, leading to vasodilation and a reduction in blood pressure.
Additionally, Dehydro Azelnidipine is used as a component in the formulation of drugs targeting atherosclerosis due to its anti-atherosclerotic effects, which can help in the prevention and treatment of cardiovascular diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 918659-10-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,8,6,5 and 9 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 918659-10:
(8*9)+(7*1)+(6*8)+(5*6)+(4*5)+(3*9)+(2*1)+(1*0)=206
206 % 10 = 6
So 918659-10-6 is a valid CAS Registry Number.
918659-10-6Relevant articles and documents
Identification and synthesis of impurities formed during preparation of azelnidipine
Rao, K. Sudarshan,Rao, K. Nageswara,Chavan, Bhausaheb,Muralikrishna,Jayashree
, p. 4675 - 4678 (2014/12/10)
Azelnidipine (1), dihydropyridine-based calcium antagonists (DHPs) are one of the widely used drugs for treatment of hypertension. During the laboratory optimization and later during its bulk synthesis the formation of various impurities was observed. The impurities formed were monitored and their structures were tentatively assigned on the basis of their fragmentation patterns in LC-MS. Most of the impurities were synthesized and their assigned constitutions confirmed by co-injection in HPLC. We describe herein the formation, synthesis and characterization of these impurities. Our study will be of immense help to others to obtain chemically high pure azelnidipine.