919091-64-8Relevant articles and documents
Highly functionalized dispiro oxindole-pyrrolo[1,2-c]thiazole-piperidone hybrid: Synthesis, characterization and theoretical investigations on the regiochemistry
Suresh Kumar, Raju,Almansour, Abdulrahman I.,Arumugam, Natarajan,Soliman, Saied M.,Ranjith Kumar, Raju,Ghabbour, Hazem A.
, p. 93 - 103 (2016)
The synthesis of highly functionalized dispiro oxindole-pyrrolo[1,2-c]thiazole-piperidone hybrid has been achieved regioselectively employing microwave-assisted three-component 1,3-dipolar cycloaddition. Structural elucidation of the compound has been acc
Design, synthesis and tumour-selective toxicity of novel 1-[3-{3,5-bis(Benzylidene)-4-oxo-1-piperidino}-3-oxopropyl]-4-piperidone oximes and related quaternary ammonium salts
Aguilera, Renato J.,Amano, Shigeru,Balderrama, Karol S.,Contreras, Lisett,Das, Umashankar,Dimmock, Jonathan R.,Roayapalley, Praveen K.,Sakagami, Hiroshi,Sharma, Rajendra K.
, (2021/12/09)
A novel series of 1-[3-{3,5-bis(benzylidene)-4-oxo-1-piperidino}-3-oxopropyl]-4-piperidone oximes 3a–h and related quaternary ammonium salts 4a–h were prepared as candidate antineoplastic agents. Evaluation against neoplastic Ca9-22, HSC-2 and HSC-4 cells
Highly functionalized 2-amino-4H-pyrans as potent cholinesterase inhibitors
Kumar, Raju Suresh,Almansour, Abdulrahman I.,Arumugam, Natarajan,Al-thamili, Dhaifallah M.,Basiri, Alireza,Kotresha,Manohar, Thota Sai,Venketesh,Asad, Mohammad,Asiri, Abdullah M.
, p. 134 - 143 (2018/08/21)
Novel highly functionalized 2-amino-4H-pyrans were achieved in excellent yields under simple grinding at ambient temperature and were assessed for their potential for treating Alzheimer's disease (AD). The 2-amino-4H-pyran bearing nitro groups on both the aryl rings showed the highest activity, with an IC50 of 1.98 ± 0.09 μM against acetylcholinesterase (AChE) and 10.62 ± 0.21 μM against butyrylcholinesterase (BChE), the inhibition mechanisms on AChE and BChE receptors were revealed by means of molecular docking simulations.
