919116-69-1

Basic information

• Product Name: Benzoic acid, 4-[(1,4-dihydro-4-oxo-2-pyrimidinyl)amino]-
• CAS NO: 919116-69-1
• Molecular Formula: C11H9N3O3
• Molecular Weight: 231.211
• Mol File: 919116-69-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[(1,4-dihydro-4-oxo-2-pyrimidinyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[(1,4-dihydro-4-oxo-2-pyrimidinyl)amino]-(919116-69-1)
• EPA Substance Registry System: Benzoic acid, 4-[(1,4-dihydro-4-oxo-2-pyrimidinyl)amino]-(919116-69-1)

Safety Data

• Hazardous Substances Data: 919116-69-1(Hazardous Substances Data)

Upstream product

• 5751-20-2 2-Methylthiouracil 
• 150-13-0 4-amino-benzoic acid 
• 619-45-4 4-methoxycarbonyl aniline 
• 873225-52-6 4-(4-hydroxy-pyrimidin-2-ylamino)-benzoic acid methyl ester 

Downstream Products

• 919116-71-5 4-(5-bromo-6-oxo-1,6-dihydro-pyrimidin-2-ylamino)-benzoic Acid 
• 919116-70-4 4-(5-iodo-6-oxo-1,6-dihydropyrimidin-2-ylamino)benzoic acid 
• 873225-54-8 [4-(4-hydroxy-pyrimidin-2-ylamino)-phenyl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone 
• 873225-55-9 [4-(4-chloro-pyrimidin-2-ylamino)-phenyl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone 
• 873225-53-7 4-(4-hydroxy-pyrimidin-2-ylamino)-benzoyl chloride 

Relevant articles and documents

New compounds

The present invention encompasses compounds of general formula (1) wherein R1, R2, R4, X, m, n and p are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a pharmaceutical composition having the above-mentioned properties.

Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK

The design, synthesis, and the biological evaluation of 2-benzamido-pyrimidines as novel IKK inhibitors are described. By optimization of the lead compound 3, compounds 16 and 24 are identified as good inhibitors of IKK2 with IC50 values of 40 and 25 nM, respectively. Compound 16 also demonstrated significant in vivo activity in an acute model of cytokine release.