919363-09-0Relevant articles and documents
Development of a Scalable and Practical Synthesis of AB928, a Dual A2a/A2bReceptor Antagonist
Debien, Laurent P. P.,Jeffrey, Jenna L.,Leleti, Manmohan R.,Miles, Dillon H.,Powers, Jay P.,Rosen, Brandon R.,Sharif, Ehesan U.
, p. 1254 - 1261 (2020/08/14)
AB928 is a potent and selective dual antagonist of the A2a and A2b receptors, which is currently in clinical trials. Here, we report the development of two scalable and practical syntheses of AB928. The first-generation synthesis was used to successfully
As opioid receptor antagonists or inverse agonists of the novel compounds
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Paragraph 0335-0337; 0338-0340, (2016/10/08)
Novel compounds which are antagonists or inverse agonists at one or more of the opioid receptors, pharmaceutical compositions containing them, to processes for their preparation.
NOVEL PKC INHIBITORS
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Page/Page column 46, (2012/12/13)
The present invention relates to new kinase inhibitors, more specifically PKCθ inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular,