919535-10-7Relevant articles and documents
SECO-CYCLOPROPAPYRROLOINDOLE COMPOUNDS, ANTIBODY-DRUG CONJUGATES THEREOF, AND METHODS OF MAKING AND USE
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, (2018/03/09)
seco-Cyclopropapyrroloindole compounds of formula (I) where Hal, R1, R2, and R3 are as defined in the application, are potent anti-cancer agents that can be used in antibody-drug conjugates.
Solid-Phase Synthesis of Duocarmycin Analogues and the Effect of C-Terminal Substitution on Biological Activity
Stephenson, Michael J.,Howell, Lesley A.,O'Connell, Maria A.,Fox, Keith R.,Adcock, Claire,Kingston, Jenny,Sheldrake, Helen,Pors, Klaus,Collingwood, Stephen P.,Searcey, Mark
, p. 9454 - 9457 (2015/10/12)
The duocarmycins are potent antitumor agents with potential for use in the development of antibody-drug conjugates (ADCs) as well as being clinical candidates in their own right. In this article, we describe the synthesis of a duocarmycin monomer (DSA) th