91970-36-4Relevant articles and documents
Electrochemical Oxidation Enables Regioselective and Scalable α-C(sp3)-H Acyloxylation of Sulfides
Wang, Huamin,He, Meng,Li, Yongli,Zhang, Heng,Yang, Dali,Nagasaka, Masanari,Lv, Zongchao,Guan, Zhipeng,Cao, Yangmin,Gong, Fengping,Zhou, Zhilin,Zhu, Jingyun,Samanta, Supravat,Chowdhury, Abhishek Dutta,Lei, Aiwen
supporting information, p. 3628 - 3637 (2021/04/07)
A highly selective, environmentally friendly, and scalable electrochemical protocol for the construction of α-acyloxy sulfides, through the synergistic effect of self-assembly-induced C(sp3)-H/O-H cross-coupling, is reported. It features exceptionally broad substrate scope, high regioselectivity, gram-scale synthesis, construction of complex molecules, and applicability to a variety of nucleophiles. Moreover, the soft X-ray absorption technique and a series of control experiments have been utilized to demonstrate the pivotal role of the self-assembly of the substrates, which indeed is responsible for the excellent compatibility and precise control of high regioselectivity in our electrochemical protocol.
Method for preparing alkylthiomethyl ester compounds
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Paragraph 0041; 0042, (2017/08/31)
The invention discloses a method for preparing alkylthiomethyl ester compounds and belongs to the field of organic chemistry. The method disclosed by the invention comprises the following steps: dissolving sulfoxide, an iron salt reagent and an alkali in a non-protonic solvent under inert gas shielding; adding an acyl chloride reagent into the system, stirring and reacting to enable alpha-carbon rearranged by sulfoxide molecules to combine with acyloxy transformed by acyl chloride molecules, thereby obtaining the alkylthiomethyl ester. The method disclosed by the invention is simple in reaction, mild in conditions, low in cost and wide in application range; and the reaction product can become an important and effective carboxyl protecting group, and the absorption effect of certain drugs can be improved.
