92035-59-1

Basic information

• Product Name: 2-phenylcycloheptan-1-ol
• Synonyms: 2-phenylcycloheptan-1-ol
• CAS NO: 92035-59-1
• Molecular Weight: 190.285
• Mol File: 92035-59-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-phenylcycloheptan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenylcycloheptan-1-ol(92035-59-1)
• EPA Substance Registry System: 2-phenylcycloheptan-1-ol(92035-59-1)

Safety Data

• Hazardous Substances Data: 92035-59-1(Hazardous Substances Data)

Upstream product

• 14996-78-2 2-phenylcycloheptanone 
• 97-72-3 2-Methylpropionic anhydride 
• 286-45-3 8-oxabicyclo[5.1.0]octane 
• 108-86-1 bromobenzene 
• 502-42-1 cycloheptanone 
• 25308-75-2 1-Phenylcycloheptene 

Downstream Products

• 112665-43-7 seratrodast 
• 211870-29-0 2-phenyl-1-(trimethylsilyloxy)cyclohept-1-ene 
• 14996-78-2 2-phenylcycloheptanone 

Relevant articles and documents

Synthesis method of chiral trans-2-substituted naphthenic alcohol

The invention relates to a synthesis method of chiral trans-2-substituted naphthenic alcohol. The invention provides a method for synthesizing chiral trans-cycloalkanol through asymmetric hydrogenation of palladium-catalyzed 2-substituted cyclic ketone. According to the method,a chiral diphosphine P-P * complex of metal palladium is taken as a catalyst, an acid additive is used in cooperation, asymmetric hydrogenation is carried out on a 2-substituted cyclic ketone compound to obtain a corresponding chiral trans-cycloalkanol compound. the enantiomeric excess of the chiral trans-cycloalkanol compound can reach 97% at most, and the trans-selectivity of the chiral trans-cycloalkanol compound is up to 20: 1. The method is simple and convenient to operate, practical, easy to implement, high in yield, high in atom economy and environment-friendly; the catalyst is commercially available; the reaction conditions are mild; and the method has a potential practical application value.

Catalytic Redox Chain Ring Opening of Lactones with Quinones to Synthesize Quinone-Containing Carboxylic Acids

Catalytic ring opening of five- to eight-membered lactones with quinones is achieved through a redox chain mechanism. With low loading of a simple metal triflate Lewis acid catalyst and a chain initiator, C-H bonds of many quinones were efficiently functionalized with carboxylic acid-containing side chains. This method also features 100% atom economy and wide substrate scope. A novel route to the anti-asthma drug Seratrodast was developed. Mechanism study suggests that the redox chain reaction likely undergoes a carbocation intermediate.

Discovery of N-(2-aryl-cyclohexyl) substituted spiropiperidines as a novel class of GlyT1 inhibitors

Screening of the Roche compound library led to the identification of cis-N-(2-phenyl-cyclohexyl)-spiropiperidine 1 as structurally novel GlyT1 inhibitor. The SAR, which was developed in this series, resulted in the discovery of highly potent compounds displaying excellent selectivity against the GlyT2 isoform.