920966-02-5

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 4-chloro-
• Synonyms: 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 4-chloro-;4-Chloro-1H-Pyrrollo[2,3-b]pyridine-5-carbonitrile;4-Chloro-5-cyano-7-azaind...;4-Chloro-5-cyano-7-azaindole;3-b]pyridine-5-carbonitrile
• CAS NO: 920966-02-5
• Molecular Formula: C₈H₄ClN₃
• Molecular Weight: 177.59
• Mol File: 920966-02-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.50
• Refractive Index: 1.696
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 11.60±0.40(Predicted)
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 4-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 4-chloro-(920966-02-5)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 4-chloro-(920966-02-5)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• Hazardous Substances Data: 920966-02-5(Hazardous Substances Data)

Usage

General Description

1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 4-chloro is a chemical compound with the molecular formula C9H5ClN2. It is a derivative of pyrrolopyridine, which is often used in the pharmaceutical industry as a building block for the synthesis of various biologically active compounds. The 4-chloro substituent on the carbonitrile moiety makes this compound particularly valuable for use in medicinal chemistry, as it can potentially enhance the molecule's pharmacological properties. This chemical may have potential applications in the development of new drugs and treatments for various diseases. However, it is important to handle and use this compound with care due to its potential reactivity and toxicity.

InChI:InChI=1/C8H4ClN3/c9-7-5(3-10)4-12-8-6(7)1-2-11-8/h1-2,4H,(H,11,12)

Upstream product

• 920966-13-8 4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carboxamide 
• 920966-03-6 4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid 

Downstream Products

• 1251908-00-5 1-[(3S,4S)-1-benzyl-4-methylpiperidin-3-yl]-1,6-dihydrodipyrrolo[2,3-b:2',3'-d]pyridine 
• 1251907-99-9 1-[(3R,4R)-1-benzyl-4-methylpiperidin-3-yl]-1,6-dihydrodipyrrolo[2,3-b:2',3'-d]pyridine 
• 1309431-03-5 4-chloro-3-(2,6-difluoro-3-nitro-benzoyl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile 

Relevant articles and documents

JAK KINASE INHIBITOR, PREPARATION METHOD FOR SAME, AND APPLICATIONS THEREOF IN FIELD OF MEDICINE

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CONDENSED PYRIDINE COMPOUND

The present invention provides a compound having excellent JAK3 inhibitory activity and being useful as an active ingredient of an agent for treating and/or preventing various immune diseases including autoimmune diseases, inflammatory diseases, and allergic diseases. As a result of investigations with respect to novel condensed heterocyclic derivatives, the inventors have verified that a condensed pyridine compound has excellent JAK3 inhibitory activity, thereby completing the present invention. More specifically, it has been verified that since the compound according to the present invention has inhibitory activity against JAK3, the compound is useful as an active ingredient of an agent for treating or preventing diseases caused by undesirable cytokine signal transduction (e.g., rejection during live organ/tissue transplantation, autoimmune diseases, asthma, atopic dermatitis, rheumatism, psoriasis and atherosclerotic disease), or diseases caused by abnormal cytokine signal transduction (e.g., cancer and leukemia).