921-88-0

Basic information

• Product Name: 2,2-dichloro-N,N-diethylacetamide
• Synonyms: 2,2-dichloro-N,N-diethylacetamide;N,N-Diethyldichloroacetamide
• CAS NO: 921-88-0
• Molecular Formula: C₆H₁₁Cl₂NO
• Molecular Weight: 184.06364
• EINECS: 213-072-5
• Mol File: 921-88-0.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 217.1°Cat760mmHg
• Flash Point: 85.1°C
• Appearance: /
• Density: 1.186g/cm³
• Vapor Pressure: 0.135mmHg at 25°C
• Refractive Index: 1.469
• PKA: -1.36±0.70(Predicted)
• CAS DataBase Reference: 2,2-dichloro-N,N-diethylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-dichloro-N,N-diethylacetamide(921-88-0)
• EPA Substance Registry System: 2,2-dichloro-N,N-diethylacetamide(921-88-0)

Safety Data

• Hazardous Substances Data: 921-88-0(Hazardous Substances Data)

Usage

General Description

2,2-dichloro-N,N-diethylacetamide is a chemical compound with the molecular formula C6H10Cl2NO. It is used as a topical repellent against insects and ticks. 2,2-dichloro-N,N-diethylacetamide has also been studied for its potential use as an agent for the treatment and prevention of malaria. In addition, it has shown promising results in laboratory tests for its ability to protect against yellow fever mosquitoes. However, further research is necessary to fully understand its efficacy and safety for these applications. It is important to handle this compound with caution, as it can be harmful if ingested or inhaled.

InChI:InChI=1/C6H11Cl2NO/c1-3-9(4-2)6(10)5(7)8/h5H,3-4H2,1-2H3

Upstream product

• 79-36-7 dichloroacethyl chloride 
• 109-89-7 diethylamine 
• 121-44-8 triethylamine 
• 18342-53-5 β-bromoethyl α,α-dichloroacetoacetate 
• 16967-79-6 trichloroethylene epoxide 
• 67406-60-4 2,2-dichloro-1,1-difluoroethyldiethylamine 
• 2430-00-4 2,2,2-trichloro-N,N-diethylacetamide 
• 686-10-2 N,N-diethyl-1,2,2-trichlorovinylamine 
• 35301-47-4 4-chloro-3,3,4-trifluoro-2-methyl-butan-1-ol 

Downstream Products

• 1310802-56-2 (E)-N,N-diethyl-3-O-benzyl-5,6-dideoxy-1,2-O-isopropylidene-α-D-xylo-hept-5-enofuranosiduronamide 
• 1219097-04-7 2-chloro-3-cyclohexyl-N,N-diethyl-3-(tosylamino)propanamide 
• 1219097-03-6 2-chloro-N,N-diethyl-4-methyl-3-(tosylamino)hexanamide 
• 123827-90-7 3-(4-chlorophenyl)-1-diethylamino-2-propen-1-one 
• 23784-83-0 (E)-N,N-diethyl-3-(4-methoxyphenyl)propenamide 
• 27829-46-5 (E)-N,N-diethyl-3-phenylacrylamide 
• 948916-65-2 (E)-3-cyclohexyl-N,N-diethylacrylamide 
• 956830-83-4 2,2-dichloro-N,N-diethyl-3-phenylpropionamide 
• 302571-80-8 (E)-N,N-Diethyl-4-phenylpent-2-enamide 
• 202478-86-2 2-butyl-2,3-epoxy-N,N-diethyl-3-phenylpropanamide 

Relevant articles and documents

Synthesis process of difluoroacetic acid

The synthesis process comprises the following steps: adding dialkylamines in a dry reaction vessel, first organic solvent and volume concentration of 10 - 40% alkali liquor, dropwise adding dichloroacetyl chloride, carrying out heat preservation stirring after dropwise addition, organic subtraction pressure desolventizing and concentrating to obtain dichloroacetyl dialkylamine. Potassium fluoride, second organic solvent and dichloroacetyl dialkylamine were added to another reaction vessel, and the molar ratio @timetime@ and thermal insulation of the potassium fluoride, the solvent diethylene glycol and the dichloroacetyl 3:5:1 dialkylamine is @. The equimolar difluoroacetyl dialkylamine and the volume concentration were mixed with 10 - 30% lye, reflux was 4 - 10h, dichloroacetyl dialkylamine was recovered by distillation, and the bottoms of the bottoms were adjusted pH=1 with hydrochloric acid and distilled again to give difluoro acetic acid.

Transformations of N-ethylamines into amide derivatives under the action of sulfur monochloride

Tertiary N-ethylamines were converted into amide derivatives by reactions with sulfur monochloride and DABCO at 0 °C. Depending on the nature of the substituents in the amine, the reaction can be accompanied by unexpected transformations.

Direct conversion of N-ethylamines into functionalised amides by S2Cl2

Hünig's base 1 is known to react extensively with S2Cl2 to give monocyclic, bicyclic and fused tricyclic 1,2-dithioles with the N-ethyl group intact, but with S2Cl2 and DABCO in chloroform at 0 °C 1 is converted