921040-01-9

Basic information

• Product Name: Pyrazine, 5-(chloromethyl)-2,3-dimethyl-
• Synonyms: Pyrazine, 5-(chloromethyl)-2,3-dimethyl-
• CAS NO: 921040-01-9
• Molecular Formula: C7H9ClN2
• Molecular Weight: 0
• Mol File: 921040-01-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyrazine, 5-(chloromethyl)-2,3-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrazine, 5-(chloromethyl)-2,3-dimethyl-(921040-01-9)
• EPA Substance Registry System: Pyrazine, 5-(chloromethyl)-2,3-dimethyl-(921040-01-9)

Safety Data

• Hazardous Substances Data: 921040-01-9(Hazardous Substances Data)

Upstream product

• 87-90-1 trichloroisocyanuric acid 
• 14667-55-1 2,3,5-trimethylpyrazine 

Relevant articles and documents

Hederagenin compound H-X with anti-lung cancer effect and preparation method and application thereof

The invention provides a hederagenin compound H-X with an anti-tumor effect and a preparation method and application thereof. The structural general formula 1 is shown in the specifications. Most of the derivatives provided by the invention have obvious inhibition effects on tumor cells A549, MCF-7 and HepG2, and the compound hederagenin-2, 6-dimethylpyrazine (H-08) shows good selectivity betweentumors and normal conditions, especially on lung cancer A549 cells. The IC50 of the compound to A549, MCF-7, HepG2, MDCK and H9c2 is 3.45+/-0.59 muM, 8.73+/-1.49 muM, 8.71+/-0.38 muM, 14.11+/-0.04 muM, and 16.69+/-0.12 muM, the inhibition effect on A549 cells is similar to that of a positive drug cis-platinum (IC50 is 3.85+/-0.63 muM), but the toxicity on MDCK and H9c2 is obviously lower than thatof cis-platinum.

N-(Heteroaryl)-1-heteroarylalkyl-1H-indole-2-carboxamide derivatives, preparation and therapeutic use thereof

The invention concerns compounds of general formula (I), wherein n, X1, X2, X3, X4, Y and W are as defined herein. The invention also concerns a method for preparing said compounds and their therapeutic use.