921626-36-0Relevant articles and documents
Efficient one-pot synthesis of the GABAB positive allosteric modulator (R,S)-5,7-Di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2- one
Alker, Andre M.,Grillet, Francois,Malherbe, Pari,Norcross, Roger D.,Thomas, Andrew W.,Masciadri, Raffaello
, p. 3398 - 3405 (2008)
The GABAB positive allosteric modulator (R,S)-5,7-di-tert-butyl- 3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one (1) was synthesized in one pot from the anhydrous lithium salt of 2,4-di-tert-butylphenol and methyl trifluoropyruvate mediated by a stoichiometric amount of anhydrous gallium(III) chloride in 64% overall yield. The enantiomers of 1 were separated by chiral-phase HPLC (Chiralpak AD), and the absolute configuration was determined by X-ray crystallography. Copyright Taylor & Francis Group, LLC.