922139-40-0

Basic information

• Product Name: (2S,4S)-1-BOC-2-HYDROXYMETHYL-4-AMINO PYRROLIDINE-HCL
• Synonyms: (2S,4S)-1-BOC-2-HYDROXYMETHYL-4-AMINO PYRROLIDINE-HCL;1-N-BOC-4(S)-AMINO-2(S)-HYDROXYMETHYL PYRROLIDINE HYDROCHLORIDE;(2S,4S)-tert-butyl 4-amino-2-(hydroxymethyl)pyrrolidine-1-carboxylate;1-N-Boc-4(S)-Amino-2(S)-hydroxymethyl pyrrolidine;(2S,4S)-4-Amino-2-(hydroxymethyl)-1-pyrrolidinecarboxylic acid tert-butyl ester;TERT-BUTYL (3S,5S)-3-AMINO-5-(HYDROXYMETHYL)PYRROLIDINECARBOXYLATE
• CAS NO: 922139-40-0
• Molecular Formula: C₁₀H₂₀N₂O₃
• Molecular Weight: 216.28
• Mol File: 922139-40-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 323.3±27.0 °C(Predicted)
• Appearance: /
• Density: 1.120±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 14.77±0.10(Predicted)
• CAS DataBase Reference: (2S,4S)-1-BOC-2-HYDROXYMETHYL-4-AMINO PYRROLIDINE-HCL(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4S)-1-BOC-2-HYDROXYMETHYL-4-AMINO PYRROLIDINE-HCL(922139-40-0)
• EPA Substance Registry System: (2S,4S)-1-BOC-2-HYDROXYMETHYL-4-AMINO PYRROLIDINE-HCL(922139-40-0)

Safety Data

• Hazardous Substances Data: 922139-40-0(Hazardous Substances Data)

Usage

General Description

(2S,4S)-1-BOC-2-HYDROXYMETHYL-4-AMINO PYRROLIDINE-HCL is a chemical compound that is a derivative of pyrrolidine. It is a hydrochloride salt form of the compound, which means it is in a stable, water-soluble form. The compound has a BOC (tert-butyloxycarbonyl) protecting group on the 1 position, and a hydroxymethyl and amino group on the 2 and 4 positions, respectively. (2S,4S)-1-BOC-2-HYDROXYMETHYL-4-AMINO PYRROLIDINE-HCL has potential uses in organic synthesis, pharmaceuticals, and as a building block for the synthesis of other chemical compounds.

Upstream product

• 149152-68-1 (2S,4S)-1-tert-butyl 2-methyl 4-(((benzyloxy)carbonyl)amino)pyrrolidine-1,2-dicarboxylate 
• 1932593-75-3 tert-butyl (2S,4S)-4-(((benzyloxy)carbonyl)amino)-2-(hydroxymethyl)pyrrolidin-1-carboxylate 
• 84520-67-2 (2S,4R)-4-(methylsulfonyloxy)pyrrolidine-1,2-dicarboxylic acid 1-tert-butylester-2-methylester 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 84520-68-3 N-tert-butoxycarbonyl-cis-4-azido-L-proline methyl ester 
• 418793-92-7 1-(N-Boc)-4(S)-azido-pyrrolidine-2(S)-methyl alcohol 

Downstream Products

• 113451-59-5 (1S,4S)-2,5-Diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester 
• 1161931-72-1 (2S,4S)-4-(4-bromo-2-nitro-phenylamino)-2-hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

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Provided are an irreversible inhibitor of a fibroblast growth factor receptor (FGFR) as indicated by formula I, a pharmaceutically acceptable salt, a stereoisomer, a pharmaceutical preparation, a pharmaceutical composition and an application thereof. R1, R2, R3, R4, ring A, Ar, ring B and warhead are as defined in the specification. The compound has high-efficiency and high-selectivity inhibition of a fibroblast growth factor receptor and can be applied to treatment of abnormal FGF/FGFR-mediated diseases, in particular the treatment of cancers.

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