922178-61-8

Basic information

• Product Name: (R)-3-METHYL-2-KETOPIPERAZINE
• Synonyms: (R)-3-METHYL-2-KETOPIPERAZINE;(R)-3-METHYL-2-OXO-PIPERAZINE;(R)-3-METHYL-PIPERAZIN-2-ONE;2-Piperazinone, 3-Methyl-, (3R)-
• CAS NO: 922178-61-8
• Molecular Formula: C₅H₁₀N₂O
• Molecular Weight: 114.15
• EINECS: 1592732-453-0
• Mol File: 922178-61-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 289.6±33.0 °C(Predicted)
• Appearance: /
• Density: 0.992±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 15.51±0.40(Predicted)
• CAS DataBase Reference: (R)-3-METHYL-2-KETOPIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-METHYL-2-KETOPIPERAZINE(922178-61-8)
• EPA Substance Registry System: (R)-3-METHYL-2-KETOPIPERAZINE(922178-61-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36-43
• Safety Statements: 26-36/37
• WGK Germany: 2
• F: 10
• Hazardous Substances Data: 922178-61-8(Hazardous Substances Data)

Usage

General Description

(R)-3-Methyl-2-ketopiperazine is a chemical compound with a molecular formula of C6H10N2O. It is a derivative of piperazine and belongs to the class of organic compounds known as alpha-ketoamides. (R)-3-METHYL-2-KETOPIPERAZINE is most commonly used as a building block for the synthesis of pharmaceuticals and other chemicals. It is known for its potential biological activity and has been studied for its potential use in the treatment of various medical conditions. Additionally, it has been found to have antimicrobial properties, making it a valuable compound for various industrial applications. Overall, (R)-3-methyl-2-ketopiperazine is a versatile and important chemical with a wide range of potential uses.

Upstream product

• 71283-66-4 (-)-(S)-Methyl 2-<(p-tolylsulfonyl)oxy>propionate 
• 107-15-3 ethylenediamine 
• 23936-11-0 3-methylpiperazin-2-one 
• 1346681-71-7 (1E)-4-hydroxy-1-mesityl-4-methylpent-1-en-3-one 

Downstream Products

• 1629229-82-8 (R)-tert-butyl 2-methyl-3-oxopiperazine-1-carboxylate 
• 1429556-99-9 (R)-(8-methyl-3-(2-methylthiazol-4-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)(4-(thiophen-2-yl)phenyl)methanone 
• 1429607-62-4 (R)-4-(7-(2,4-dimethoxybenzyl)-8-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-2-methylthiazole 
• 1429560-52-0 (R)-1-(2,4-dimethoxybenzyl)-5-ethoxy-6-methyl-1,2,3,6-tetrahydropyrazine 
• 1383146-20-0 (R)-4-(2,4-dimethoxybenzyl)-3-methylpiperazin-2-one 
• 1354947-67-3 (3R)-3-methyl-4-({1-[4-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)-2-piperazinone 
• 1354946-40-9 (3R)-1-ethyl-3-methyl-4-({1-[4-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)-2-piperazinone 

Relevant articles and documents

Selective NK-3 receptor antagonist, preparation and application thereof

The invention provides a selective NK-3 receptor antagonist, preparation and application thereof, particularly a compound represented by the following formula (I). The compound of the invention has unexpected activity to modulate cytokines and/or interferon, and is useful in the treatment of CNS and peripheral diseases or disorders.

KINETIC RESOLUTION OF CHIRAL AMINES

The present invention refers to a method for the kinetic resolution of a chiral primary or secondary amine by treating the amine with a chiral, hydroxamic acid derived reagent of the formula (I). These chiral reagents are particularly useful for the kinetic resolution of cyclic amines and may be generated in situ in the presence of an N-heterocyclic carbene, thus allowing for a catalytic reaction.