922525-73-3

Basic information

• Product Name: Methanone, [4'-(1,1-dimethylethyl)[1,1'-biphenyl]-3-yl]-9H-pyrido[3,4-b]indol-1-yl-
• CAS NO: 922525-73-3
• Molecular Formula: C28H24N2O
• Molecular Weight: 404.511
• Mol File: 922525-73-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Methanone, [4'-(1,1-dimethylethyl)[1,1'-biphenyl]-3-yl]-9H-pyrido[3,4-b]indol-1-yl-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, [4'-(1,1-dimethylethyl)[1,1'-biphenyl]-3-yl]-9H-pyrido[3,4-b]indol-1-yl-(922525-73-3)
• EPA Substance Registry System: Methanone, [4'-(1,1-dimethylethyl)[1,1'-biphenyl]-3-yl]-9H-pyrido[3,4-b]indol-1-yl-(922525-73-3)

Safety Data

• Hazardous Substances Data: 922525-73-3(Hazardous Substances Data)

Upstream product

• 906067-46-7 (3-bromophenyl)-(9H-β-carbolin-1-yl)-methanone 
• 123324-71-0 p-tert-butylphenylboronic acid 

Relevant articles and documents

Synthesis, crystal structure and biological activity of β-carboline based selective CDK4-cyclin D1 inhibitors

The design, synthesis and biological activity of a series of non-planar dihydro-β-carboline and β-carboline-based derivatives of the toxic anticancer agent fascaplysin is presented. We show these compounds to be selective inhibitors of CDK4 over CDK2 with an IC50 (CDK4-cyclin D1) = 11 mol for the best compound in the series 4d. The crystallographic analysis of some of the compounds synthesised (3b/d and 4a-d) was carried out, in an effort to estimate the structural similarities between the designed inhibitors and the model compound fascaplysin. The Royal Society of Chemistry.