923002-43-1

Basic information

• Product Name: 3-Pyridinecarboxylic acid, 4-(2-ethylphenyl)-1,4,5,6-tetrahydro-2-phenyl-1-(3-pyridinylmethyl)-, 2-propen-1-yl ester
• CAS NO: 923002-43-1
• Molecular Formula: C29H30N2O2
• Molecular Weight: 438.569
• Mol File: 923002-43-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Pyridinecarboxylic acid, 4-(2-ethylphenyl)-1,4,5,6-tetrahydro-2-phenyl-1-(3-pyridinylmethyl)-, 2-propen-1-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxylic acid, 4-(2-ethylphenyl)-1,4,5,6-tetrahydro-2-phenyl-1-(3-pyridinylmethyl)-, 2-propen-1-yl ester(923002-43-1)
• EPA Substance Registry System: 3-Pyridinecarboxylic acid, 4-(2-ethylphenyl)-1,4,5,6-tetrahydro-2-phenyl-1-(3-pyridinylmethyl)-, 2-propen-1-yl ester(923002-43-1)

Safety Data

• Hazardous Substances Data: 923002-43-1(Hazardous Substances Data)

Upstream product

• 18282-40-1 1-ethyl-2-iodobenzene 
• 15796-65-3 3-oxo-3-phenylpropionic acid allyl ester 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 103907-09-1 2-ethylcinnamaldehyde 
• 3731-52-0 3-Aminomethylpyridine 
• 923002-42-0 C₂₃H₂₄O₄ 

Relevant articles and documents

Design and synthesis of piperidine farnesyltransferase inhibitors with reduced glucuronidation potential

The design and synthesis of a novel piperidine series of farnesyltransferase (FTase) inhibitors with reduced potential for metabolic glucuronidation are described. The various substitution and exchange of the phenyl group at the C-2 position of the previously described 2-(4-hydroxy)phenyl-3-nitropiperidine 1a (FTase IC50 = 5.4 nM) resulted in metabolically stable compounds with potent FTase inhibition (14a IC50 = 4.3 nM, 20a IC50 = 3.0 nM, and 50a IC50 = 16 nM). Molecular modeling studies of these compounds complexed with FTase and farnesyl pyrophosphate are also described.