92357-91-0

Basic information

• Product Name: 1,3-Diazaspiro[4.5]decane-2,4-dione, 1,3-bis(phenylmethyl)-
• CAS NO: 92357-91-0
• Molecular Formula: C22H24N2O2
• Molecular Weight: 348.445
• Mol File: 92357-91-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,3-Diazaspiro[4.5]decane-2,4-dione, 1,3-bis(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Diazaspiro[4.5]decane-2,4-dione, 1,3-bis(phenylmethyl)-(92357-91-0)
• EPA Substance Registry System: 1,3-Diazaspiro[4.5]decane-2,4-dione, 1,3-bis(phenylmethyl)-(92357-91-0)

Safety Data

• Hazardous Substances Data: 92357-91-0(Hazardous Substances Data)

Upstream product

• 622-79-7 benzyl azide 
• 3173-56-6 benzyl isothiocyanate 
• 6721-03-5 N,N'-methanediylidenebis(1-phenylmethanamine) 
• 55106-53-1 1-bromocyclohexanecarboxylic acid 
• 100-44-7 benzyl chloride 
• 702-62-5 spiro(imidazolidine-4,1'-cyclohexane)-2,5-dione 
• 730-95-0 3-benzyl-1,3-diazaspiro[4.5]decane-2,4-dione 

Relevant articles and documents

Regioselective multicomponent sequential synthesis of hydantoins

The development of new practical and green methods for the synthesis of small heterocycles is an attractive area of research due to the well-known potential of heterocyclic small molecule scaffolds in the drug discovery process. Herein we report a one-pot, three-component sequential procedure for the synthesis of diversely 1,3,5- and 1,3,5,5-substituted hydantoins, in high yields and very mild conditions, using readily accessible starting materials such as azides, iso(thio)cyanates and substituted α-halo-acetic carboxylic acids. This methodology is especially convenient for the synthesis of spiro-hydantoins, which are particularly interesting bioactive compounds in medicinal chemistry. The Royal Society of Chemistry 2012.