92379-42-5

Basic information

• Product Name: 2,2'3,4,4'-PENTAHYDROXY BENZOPHENONE
• Synonyms: 2,2'3,4,4'-PENTAHYDROXY BENZOPHENONE;2,3,4,2',4'-PENTAHYDROXYBENZOPHENONE
• CAS NO: 92379-42-5
• Molecular Formula: C₁₃H₁₀O₆
• Molecular Weight: 262.21
• Product Categories: RAW material for Photo Active Compounds
• Mol File: 92379-42-5.mol
• Article Data: 2

Chemical Properties

• Melting Point: 187–188°C
• Appearance: /
• CAS DataBase Reference: 2,2'3,4,4'-PENTAHYDROXY BENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'3,4,4'-PENTAHYDROXY BENZOPHENONE(92379-42-5)
• EPA Substance Registry System: 2,2'3,4,4'-PENTAHYDROXY BENZOPHENONE(92379-42-5)

Safety Data

• Hazardous Substances Data: 92379-42-5(Hazardous Substances Data)

Usage

Preparation

Preparation by reaction of 2,3,4-trihydroxybenzoic acid with resorcinol, ? in the presence of zinc chloride and phosphorous oxychloride at 70–80° for 1.5 h (65%) ; ? in the presence of zinc chloride and a mixture of polyphosphoric acid/85% phosphoric acid (60:40) at 27°. Then, during 2h, phosphorous trichloride was added between 27° and 37° and the mixture heated at 60° for 16h.

Upstream product

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Relevant articles and documents

Evaluation of polyhydroxybenzophenones as α-glucosidase inhibitors

This experiment was designed to synthesize 18 kinds of polyhydroxybenzophenones by using Friedel-Crafts reaction, and to measure the inhibitory activity on α-glucosidase with p-nitrophenyl-β-D- galactopyranoside (PNPG) as a substrate. Here, acarbose (IC50a= a1674.75aaμmolaL-1) was used as the reference inhibitor. The results demonstrated that most of the target compounds had remarkable inhibitory activities on α-glucosidase. Among all these compounds, 2,4,4′,6-butahydroxydiphenylketone (11) was found to be the most potent α-glucosidase inhibitor with an IC50 value of 10.62aaμmolaL-1. In addition, we found these compounds were competitive inhibitors through the kinetic analysis. The results suggested that such compounds might be utilized for the development of new candidates for diabetes treatment. A series of polyhydroxybenzophenones was synthesized and evaluated as α-glucosidase inhibitors. Compound 11 was found to be the most potent inhibitor. Copyright