923862-84-4

Basic information

• Product Name: 2,3-dihydro-2-(2,3-dichlorophenyl)quinazolin-4(1H)-one
• Synonyms: 2,3-dihydro-2-(2,3-dichlorophenyl)quinazolin-4(1H)-one
• CAS NO: 923862-84-4
• Molecular Weight: 293.152
• Mol File: 923862-84-4.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2,3-dihydro-2-(2,3-dichlorophenyl)quinazolin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dihydro-2-(2,3-dichlorophenyl)quinazolin-4(1H)-one(923862-84-4)
• EPA Substance Registry System: 2,3-dihydro-2-(2,3-dichlorophenyl)quinazolin-4(1H)-one(923862-84-4)

Safety Data

• Hazardous Substances Data: 923862-84-4(Hazardous Substances Data)

Upstream product

• 118-48-9 isatoic anhydride 
• 6334-18-5 2,3-dichlorobenzylaldehyde 
• 612-24-8 o-nitrobenzonitrile 
• 28144-70-9 anthranilic acid amide 

Relevant articles and documents

Glucose as an Eco-Friendly Reductant in a One-Pot Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones

Carbohydrates such as glucose are an abundant renewable resource that can be employed in synthetic processes as a source of carbon and/or hydrogen to yield products of high economical and biological impact. Herein, we report a versatile and environmentally friendly protocol for the one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones, a privileged scaffold in medicinal chemistry, based on the use of glucose as an eco-friendly reductant in alkaline aqueous medium. This method can be viewed as a blueprint for the development of further one-pot sequences involving glucose as a reductant.

Synthesis of 2,3-dihydroquinazolinones and quinazolin-4(3H)-ones catalyzed by graphene oxide nanosheets in an aqueous medium: "on-water" synthesis accompanied by carbocatalysis and selective C-C bond cleavage

Graphene oxide (GO) nanosheet catalyzed new and straightforward strategies for the construction of 2,3-dihydroquinazolinones and quinazolin-4(3H)-ones starting from anthranilamide (2-aminobenzamide) and an aldehyde/ketone in aqueous medium at room temperature have been realized. This catalyst is also found to be efficient for the expedient construction of quinazolin-4(3H)-ones starting from anthranilamide and a β-ketoester/1,3-diketone following selective C-C bond cleavage of the β-ketoester/1,3-diketone at an elevated temperature under metal and oxidant free conditions.

Efficient synthesis of 2-aryl-2,3-dihydroquinazolin-4(1H)-ones in the presence of nanocomposites under microwave irradiation

The preparation of quinazolinones has been developed by the condensation of aromatic aldehydes and 2-aminobenzamide in the presence of transition metal-CNTs nanocomposites as novel and recyclable catalyst under microwave and solvent-free conditions. This methodology provides a high speed path for the green and mild synthesis of 2-aryl-2,3-dihydroquinazolin-4(1H)-ones with high structural diversity. The present methodology has advantages such as high activity and reusability of catalysts, heterogeneous nature of catalysts, no use of hazardous organic solvents and green conditions.