923942-36-3

Basic information

• Product Name: 5-Thiazolecarboxylic acid, 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-, 2-methylpropyl ester
• CAS NO: 923942-36-3
• Molecular Formula: C20H24N2O3S
• Molecular Weight: 372.488
• Mol File: 923942-36-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-Thiazolecarboxylic acid, 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-, 2-methylpropyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Thiazolecarboxylic acid, 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-, 2-methylpropyl ester(923942-36-3)
• EPA Substance Registry System: 5-Thiazolecarboxylic acid, 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-, 2-methylpropyl ester(923942-36-3)

Safety Data

• Hazardous Substances Data: 923942-36-3(Hazardous Substances Data)

Usage

General Description

5-Thiazolecarboxylic acid, 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-, 2-methylpropyl ester is a chemical compound that belongs to the thiazolecarboxylic acid ester class. It consists of a thiazole ring, a cyano group, and a methyl group attached to a phenyl ring, as well as a 2-methylpropoxy and 2-methylpropyl ester side chains. 5-Thiazolecarboxylic acid, 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-, 2-methylpropyl ester has potential applications in the pharmaceutical and chemical industries, where it may be used as a building block for the synthesis of various drugs and organic compounds. Its chemical structure and properties make it suitable for further investigation and development for various industrial and research purposes.

Upstream product

• 78-83-1 2-methyl-propan-1-ol 
• 144060-53-7 febuxostat 
• 1312815-36-3 2-(3-formyl-4-isobutyloxy phenyl)-4-methyl-thiazole-5-carboxylic acid isobutyl ester 
• 1312815-35-2 2-(3-formyl-4-hydroxy phenyl)-4-methyl-thiazole-5-carboxylic acid 
• 886501-78-6 2-(4-hydroxy phenyl)-4-methyl-thiazole-5-carboxylic acid 

Downstream Products

• 144060-53-7 febuxostat 

Relevant articles and documents

Design, synthesis, in silico and in vitro studies of novel 4-methylthiazole-5-carboxylic acid derivatives as potent anti-cancer agents

Since inhibitors of mucin onco proteins are potential targets for breast cancer therapy, a series of novel 4-methylthiazole-5-carboxylic acid (1) derivatives 3a-k were synthesized by the reaction of 1 with SOCl2followed by different bases/alcohols in the presence of triethylamine. Once synthesized and characterized, their binding modes with MUC1 were studied by molecular docking analysis using Aruglab 4.0.1 and QSAR properties were determined using HyperChem. All synthesized compounds were screened for in vitro anti-breast cancer activity against MDA-MB-231 breast adenocarcinoma cell lines by Trypan-blue cell viability assay and MTT methods. Compounds 1, 3b, 3d, 3e, 3i and 3f showed good anti-breast cancer activity. Since 1 and 3d exhibited high potent activity against MDA-MB-231 cell lines, they show could be effective mucin onco protein inhibitors.