924-46-9 Usage
Description
METHYL N-PROPYL NITROSAMINE, also known as Methylpropylnitrosamine, is a chemical compound that belongs to the class of nitrosamines. It is an organic compound with the chemical formula C4H9N3O. Nitrosamines are known for their potential carcinogenic properties and are often used in research to study the mechanisms of carcinogenesis.
Uses
Used in Biological Studies:
METHYL N-PROPYL NITROSAMINE is used in biological studies as a procarcinogen. It is utilized to investigate the bioactivation process of procarcinogens by human liver microsomal cytochrome P-450 enzymes. This enzyme plays a crucial role in the metabolism and detoxification of various compounds, including carcinogens.
Used in Toxicological Research:
METHYL N-PROPYL NITROSAMINE is also used in toxicological research to study the effects of carcinogens on biological systems. It is employed to evaluate the genotoxic potential of various compounds and their impact on DNA damage and repair mechanisms.
Used in Environmental Monitoring:
Furthermore, METHYL N-PROPYL NITROSAMINE is used in environmental monitoring to detect the presence of carcinogenic nitrosamines in various samples, such as food, water, and air. This helps in assessing the potential health risks associated with exposure to these harmful compounds and implementing necessary safety measures.
Used in the Detection of umu Gene Response:
METHYL N-PROPYL NITROSAMINE is used to study the umu gene response in Salmonella typhimurium TA 1535/pSK1002. The umu gene is involved in the DNA damage response and is activated in the presence of carcinogens. By using METHYL N-PROPYL NITROSAMINE, researchers can evaluate the genotoxic potential of various compounds and their ability to induce the umu gene response, providing valuable insights into the mechanisms of carcinogenesis and the development of potential cancer therapies.
Safety Profile
Suspected carcinogen
with experimental carcinogenic,
neoplastigenic, and tumorigenic data. Poison
by subcutaneous route. An experimental
teratogen. Mutation data reported. When
heated to decomposition it emits toxic
fumes of NOx.
Check Digit Verification of cas no
The CAS Registry Mumber 924-46-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,2 and 4 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 924-46:
(5*9)+(4*2)+(3*4)+(2*4)+(1*6)=79
79 % 10 = 9
So 924-46-9 is a valid CAS Registry Number.
InChI:InChI=1/C4H10N2O/c1-3-4-6(2)5-7/h3-4H2,1-2H3
924-46-9Relevant articles and documents
β-KETONITROSAMINES. SYNTHETIC EQUIVALENTS OF α-METHYLENE ALKYLAMINO ANIONS (-CH2NHR).
Saavedra, Joseph E.,Farnsworth, David W.,Farrelly, James G.
, p. 1147 - 1156 (2007/10/02)
β-Ketonitrosamines are important in the study of nitrosamine metabolism, carcinogenesis and in vivo alkylation.The enhanced acidity of protons at the α-carbon, as well as the ease of fragmentation of the title compounds establishes them as synthetic equivalents of α-methylene alkylamino anions (-CH2NHR).Anion formation is carried out with powdered sodium hydroxide - sodium carbonate in DMF or THF at 25 deg C.Reaction with an alkyl halide gives a good yield of the alkylated product.Retro-Claisen cleavage in aqueous basic media gives the corresponding dialkyl - nitrosamine or, with D2O, the deuterated analog.
