924-61-8

Basic information

• Product Name: ethyl 3-(dimethylamino)-3-oxopropanoate
• CAS NO: 924-61-8
• Molecular Formula: C₇H₁₃NO₃
• Molecular Weight: 159.183
• Mol File: 924-61-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 234.8°C at 760 mmHg
• Flash Point: 95.8°C
• Density: 1.047g/cm³
• Vapor Pressure: 0.0518mmHg at 25°C
• Refractive Index: 1.439
• CAS DataBase Reference: ethyl 3-(dimethylamino)-3-oxopropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(dimethylamino)-3-oxopropanoate(924-61-8)
• EPA Substance Registry System: ethyl 3-(dimethylamino)-3-oxopropanoate(924-61-8)

Safety Data

• Hazardous Substances Data: 924-61-8(Hazardous Substances Data)

Upstream product

• 105-36-2 ethyl bromoacetate 
• 105-53-3 diethyl malonate 
• 1608-26-0 Hexamethylphosphorous triamide 
• 124-40-3 dimethyl amine 
• 36239-09-5 ethyl chlorocarbonylacetate 
• 1071-46-1 hydrogen ethyl malonate 

Downstream Products

• 71509-16-5 4-methylamino-6-phenyl-6H-pyrano[3,2-c]quinoline-2,5-dione 
• 913239-78-8 2-(7-chloro-9-methyl-2-phenyl-9H-pyrimido[4,5-b]indol-4-yl)-N,N-dimethylacetamide 
• 913240-25-2 ethyl 2-(7-chloro-9-methyl-2-phenyl-9H-pyrimido[4,5-b]indol-4-yl)-3-(dimethylamino)-3-oxopropanoate 
• 1134366-03-2 (S)-2-benzyl-N,N-dimethylmalonamic acid ethyl ester 
• 157724-83-9 α-N,N-dimethylcarbamoyl-3,5-dimethoxy-4-hydroxycinnamic acid 
• 20929-39-9 N,N-Dimethyl-methyl-benzylmalonamidsaeureaethylester 
• 20929-38-8 N,N-Dimethyl-benzylmalonamidsaeuremethylester 
• 24011-69-6 2-(N-Dimethylcarbamoyl)-3-oxo-2,3-dihydro-benzoxazin-1,4 
• 26727-06-0 N,N-dimethyl-2-(2-nitro-phenoxy)-malonamic acid ethyl ester 
• 83767-08-2 8-benzil-2-(dimetilammino)cromone 
• 83767-06-0 6-benzil-2-(dimetilammino)cromone 
• 83767-00-4 2-(dimetilammino)-7-fenilcromone 
• 83766-97-6 2-(dimetilammino)-6-fenilcromone 
• 83767-03-7 2-(dimethylamino)-8-phenylchromone 

Relevant articles and documents

New succinate derivatives

The invention relates generally to new compounds of formula (I), wherein R1, R2, R3, R4, R5, R6, R7 are independently of one another and denote hydrogen, hydroxyl, C1- C6-alkyl group or R6 and R7 form together a C5-C6 ring system, and wherein n = 0, 1, 2,

The highly enantioselective phase-transfer catalytic mono-alkylation of malonamic esters

The phase-transfer catalytic alkylation of N,N-dialkylmalonamic tert-butyl esters in the presence of 1 mol% of (S,S)-3,4,5-trifluorophenyl-NAS bromide afforded highly enantioselective (S)-mono-α-alkylated products (up to 96% ee), which could be readily converted into versatile chiral building blocks without loss of chirality. The Royal Society of Chemistry.

New indium-mediated cyclisation reactions of tethered haloenynes in aqueous solvent systems

The intramolecular cyclisation of tethered allyl bromides onto terminal alkynes mediated by metallic indium proceeds smoothly and cleanly in mixtures of THF and H2O to give unsaturated carbocycles and heterocycles in good yield. Alternatively, the cyclisation may be carried out in anhydrous THF with the aid of acid catalysis. The reaction is also mediated by a range of indium salts and proceeds with substoichiometric quantities of indium in the presence of a co-reductant. Deuteration studies show that the reaction proceeds via a concerted syn carboindination of the carbon-carbon triple bond to give an intermediate, which is protonated in situ.