92410-45-2Relevant articles and documents
Possible Antineoplastic Agents: Part VIII - Synthesis and Antineoplastic Activity of 5-N-Substituted 3-p-Substituted-phenylglutaramic Acids and 5-N-Substituted 2-Benzenesulphonyl-3-phenyl-L-glutamines
De, A. U.,Mazumdar, Anjali,Jha, Tarun,Debnath, Asim Kumar
, p. 97 - 98 (2007/10/02)
A few 5-N-substituted 3-p-substituted-phenylglutaramic acids (II) and 5-N-substituted 2-benzenesulphonyl-3-phenyl-L-glutamines (V) have been synthesized as structural variants of glutamic acid and evaluated for their activity against Ehrlich ascites carcinoma (EAC) in Swiss albino mice.Quantitative structure activity relationship (QSAR) has been determined employing de novo model to the compounds.The glutaramic acids (II) exhibit better correlation and antineoplastic activity than the glutamines (V).