92444-70-7Relevant articles and documents
Method for preparing N-vinyl amide compound under catalysis of copper salt
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Paragraph 0050-0051, (2020/06/09)
The invention discloses a method for preparing an N-vinyl amide compound under the catalysis of a copper salt. The method comprises the following steps: reacting amide and vinyl alkyl ether in a closed container at 95-105 DEG C for 4-10 hours under the protection of inert gas in the presence of a copper salt catalyst and an organic solvent; and after the reaction is finished, cooling reaction liquid to room temperature, and carrying out separating and purifying to obtain the N-vinyl amide compound, wherein the copper salt catalyst is anhydrous cupric sulfate or a complex of anhydrous cupric sulfate and 8-hydroxyquinoline in a mass ratio of (2-1): 1, and a molar ratio of the amide to the vinyl alkyl ether to the copper salt catalyst is 20: (100-200): (2-1). According to the method, the simple copper salt is used as the catalyst; and compared with conventional methods, the method has the advantages that the catalyst is cheap and easy to obtain, no halogen is introduced in the reactions,the method is environmentally friendly, additives such as acid and alkali do not need to be added in the reaction, and a system is simple. The invention provides the method for effectively preparing the N-vinyl amide compound.
NEW SYNTHESIS OF SECONDARY CARBOXAMIDE BY USING 2-METHYL-2-OXAZILONE AS A BUILDING BLOCK
Inaba, Masami,Moriwake, Toshio,Saito, Seiki
, p. 3235 - 3238 (2007/10/02)
New method for the synthesis of secondary carboxamides of type, R2NHCOR1, which utilizes 2-methyl-2-oxazoline as a carboxamide building block and various halides, R2X, has been developed.
