92454-06-3Relevant articles and documents
LITHIATION OF PYRROL-2-ACETIC ACIDS. SYNTHESIS OF 2-ALKYLPYRROLES.
Muchowski, Joseph M.,Solas, Dennis R.
, p. 453 - 464 (2007/10/02)
N-methylpyrrol-2-acetic acid and pyrrol-2-acetic acid were converted into di- and trianions on reaction with two equivalents of lithium diisopropylamide or three equivalents of t-butyllithium, respectively.Reaction of the anions with one equivalent of an alkyl bromide or iodide gave the corresponding mono-α-substituted acetic acids which on thermal decarboxylation gave pure 2-alkylpyrroles.