924627-62-3Relevant articles and documents
Solvent-free, uncatalyzed asymmetric "ene" reactions of: N-Tert-butylsulfinyl-3,3,3-Trifluoroacetaldimines: A general approach to enantiomerically pure α-(trifluoromethyl)tryptamines
Mazzeo, Giuseppe,Longhi, Giovanna,Abbate, Sergio,Palomba, Martina,Bagnoli, Luana,Marini, Francesca,Santi, Claudio,Han, Jianlin,Soloshonok, Vadim A.,Di Crescenzo, Emilio,Ruzziconi, Renzo
, p. 3930 - 3937 (2017/07/11)
A novel approach to regioselectively substituted and stereoselectively α-Trifluoromethylated tryptamines is reported based on the ene reaction of Boc-protected 3-methyleneindolines with optically pure (R)-or (S)-Tert-butanesulfinyltrifluoroacetaldimine. B
Synthesis of new indole-based bisphosphonates and evaluation of their chelating ability in PE/CA-PJ15 cells
Palmerini, Carlo A.,Tartacca, Francesco,Mazzoni, Michela,Granieri, Letizia,Goracci, Laura,Scrascia, Angela,Lepri, Susan
, p. 403 - 412 (2015/09/01)
Bisphosphonates are the most important class of antiresorptive agents used against osteoclast-mediated bone loss, and, more recently, in oncology. These compounds have high affinity for calcium ions (Ca2+) and therefore target bone mineral, whe
New route to the 5,12-dihydro-7H-benzo[2,3]azepino[4,5-b]indol-6-one core via a tin-mediated indole synthesis
Henry, Nicolas,Blu, Jerome,Beneteau, Valerie,Merour, Jean-Yves
, p. 3895 - 3901 (2008/02/09)
A new route to the paullone scaffold was designed. The key step consisted in a free radical indole formation from an o-alkenyl arylisonitrile followed by Stille coupling with N-Boc-o-iodoaniline. After deprotection and closure of the seven-membered ring by lactamisation, parent or cyano-substituted paullones were obtained in moderate to good yields. Georg Thieme Verlag Stuttgart.