924854-60-4 Usage
Description
2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2S,3R,11bR)is a complex organic compound with a unique molecular structure. It belongs to the class of benzoquinolizine derivatives and features a hexahydro ring system with multiple functional groups, including methoxy and methylpropyl moieties. The stereochemistry of the compound is defined by the (2S,3R,11bR) configuration, which may influence its biological activity and interactions with target molecules.
Uses
Used in Pharmaceutical Industry:
2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2S,3R,11bR)is used as a potent inhibitor of vascular monoamine transporter 2 (VMAT2) for therapeutic and molecular imaging applications. Its ability to modulate VMAT2 activity makes it a significant agent in the development of treatments for various neurological disorders and conditions related to monoamine neurotransmitter imbalances.
Used in Molecular Imaging:
In the field of molecular imaging, 2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2S,3R,11bR)serves as a valuable tool for visualizing and studying the function and distribution of VMAT2 in biological systems. This can aid in the understanding of the role of VMAT2 in disease processes and the evaluation of potential therapeutic agents targeting this transporter.
Check Digit Verification of cas no
The CAS Registry Mumber 924854-60-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,2,4,8,5 and 4 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 924854-60:
(8*9)+(7*2)+(6*4)+(5*8)+(4*5)+(3*4)+(2*6)+(1*0)=194
194 % 10 = 4
So 924854-60-4 is a valid CAS Registry Number.
InChI:InChI=1S/C19H29NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16-17,21H,5-7,10-11H2,1-4H3/t14-,16-,17+/m1/s1
924854-60-4Relevant articles and documents
Preparation and evaluation of tetrabenazine enantiomers and all eight stereoisomers of dihydrotetrabenazine as VMAT2 inhibitors
Yao, Zhangyu,Wei, Xueying,Wu, Xiaoming,Katz, Jonathan L.,Kopajtic, Theresa,Greig, Nigel H.,Sun, Hongbin
, p. 1841 - 1848 (2011/05/07)
Tetrabenazine (TBZ) ((±)-1) and dihydrotetrabenazines (DHTBZ) are potent inhibitors of VMAT2. Herein, a practical chemical resolution of (±)-1 and stereoselective synthesis of all eight DHTBZ stereoisomers are described. The result of VMAT2 binding assay revealed that (+)-1 (Ki = 4.47 nM) was 8000-fold more potent than (-)-1 (Ki = 36,400 nM). Among all eight DHTBZ stereoisomers, (2R,3R,11bR)-DHTBZ ((+)-2: Ki = 3.96 nM) showed the greatest affinity for VMAT2. The (3R,11bR)-configuration appeared to play a key role for VMAT2 binding. In summary, (+)-1, (+)-2, and their derivatives warrant further studies in order to develop more potent and safer drugs for the treatment of chorea associated with Huntington's disease and other hyperkinetic disorders.
FLUORINATED DIHYDROTETRABENAZINE ETHER IMAGING AGENTS AND PROBES
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Page/Page column 21, (2009/05/29)
The present invention provides novel fluorinated ether compounds having structure I wherein R1 is a C2-C10 fluorinated aliphatic radical; R2 is a C1-C10 aliphatic radical, or a C3/sub
Asymmetric synthesis of tetrabenazine and dihydrotetrabenazine
Rishel, Michael J.,Amarasinghe, Kande K. D.,Dinn, Sean R.,Johnson, Bruce F.
experimental part, p. 4001 - 4004 (2009/10/14)
(Chemical Equation Presented) The enantioselective synthesis of (+)-tetrabenazine (TBZ) and (+)-dihydrotetrabenazine (DTBZ), agents of significant interest for therapeutic and molecular imaging applications, has been completed in 21% (TBZ) and 16% (DTBZ)