924867-16-3

Basic information

• Product Name: 2-(4-methoxyphenyl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one
• Synonyms: 2-(4-methoxyphenyl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one
• CAS NO: 924867-16-3
• Molecular Weight: 318.335
• Mol File: 924867-16-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(4-methoxyphenyl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one(924867-16-3)
• EPA Substance Registry System: 2-(4-methoxyphenyl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one(924867-16-3)

Safety Data

• Hazardous Substances Data: 924867-16-3(Hazardous Substances Data)

Upstream product

• 73921-19-4 5-benzoyl-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 98-88-4 benzoyl chloride 
• 100-07-2 4-methoxy-benzoyl chloride 
• 614-27-7 methyl 3-oxo-3-phenylpropionate 
• 54464-14-1 5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-amine 

Relevant articles and documents

Synthesis and in vitro anti-epileptic activities of novel [1,2,4]-triazolo[1,5-a]pyrimidin-7(4H)-one derivatives

In this investigation, eight novel 2,5-disubstituted [1,2,4]-triazolo[1,5-a]pyrimidin-7(4H)-one and eight novel 2,5-disubstituted [1,2,4]-triazolo[1,5-a]pyrimidine amine derivatives were synthesized based on the novel marine natural product Essramycin. Their anti-epileptic activities were evaluated by 4-aminopyridine (4-AP)-induced hyper excitability model in primary cultured neocortical neurons. Five compounds with [1,2,4]-triazolo[1,5-a]pyrimidin-7(4H)-one skeleton showed remarkable anti-epileptic activities. The preliminary structure–activity relationship (SAR) showed that the pyrimidine-7(4H)-one motif is the necessary “active core” of anti-epileptic activity. To understand the action mechanism of anti-epileptic activity of [1,2,4]-triazolo[1,5-a]pyrimidin-7(4H)-one compounds, docking studies using the model of GABAA as docking scaffolds were performed and the docking results were in concordance with the experiment observations. (Figure presented.).