92516-43-3

Basic information

• Product Name: Cyclopentanone, 3-benzoyl-
• CAS NO: 92516-43-3
• Molecular Formula: C12H12O2
• Molecular Weight: 188.226
• Mol File: 92516-43-3.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Cyclopentanone, 3-benzoyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopentanone, 3-benzoyl-(92516-43-3)
• EPA Substance Registry System: Cyclopentanone, 3-benzoyl-(92516-43-3)

Safety Data

• Hazardous Substances Data: 92516-43-3(Hazardous Substances Data)

Upstream product

• 930-30-3 cyclopent-2-enone 
• 5908-41-8 benzoyltrimethylsilane 
• 98-88-4 benzoyl chloride 
• 6343-27-7 1-benzoylpyrrolidine-2,5-dione 
• 120-92-3 cyclopentanone 
• 134-81-6 benzil 
• 6125-26-4 phenyl(2-phenyl-2,3-dihydrobenzo[d]thiazol-2-yl)methanone 
• 14320-37-7 3-Cyclopentenon 
• 611-73-4 Benzoylformic acid 
• 17983-39-0 2-[(trimethylsilyl)oxy]-phenylacetonitrile 
• 827-36-1 2-(N,N-dimethylamino)-2-phenylacetonitrile 
• 622-42-4 1-nitro-1-phenylmethane 
• 94517-03-0 Dimethylamino-(3-oxo-cyclopentyl)-phenyl-acetonitrile 
• 5422-88-8 phenyl cyclopentyl ketone 

Relevant articles and documents

Synergistic Activation of Amides and Hydrocarbons for Direct C(sp3)–H Acylation Enabled by Metallaphotoredox Catalysis

The utilizations of omnipresent, thermodynamically stable amides and aliphatic C(sp3)?H bonds for various functionalizations are ongoing challenges in catalysis. In particular, the direct coupling between the two functional groups has not been realized. Here, we report the synergistic activation of the two challenging bonds, the amide C?N and unactivated aliphatic C(sp3)?H, via metallaphotoredox catalysis to directly acylate aliphatic C?H bonds utilizing amides as stable and readily accessible acyl surrogates. N-acylsuccinimides served as efficient acyl reagents for the streamlined synthesis of synthetically useful ketones from simple C(sp3)?H substrates. Detailed mechanistic investigations using both computational and experimental mechanistic studies were performed to construct a detailed and complete catalytic cycle. The origin of the superior reactivity of the N-acylsuccinimides over other more reactive acyl sources such as acyl chlorides was found to be an uncommon reaction pathway which commences with C?H activation prior to oxidative addition of the acyl substrate.

Visible-Light-Promoted Synthesis of 1,4-Dicarbonyl Compounds via Conjugate Addition of Aroyl Chlorides

A facile visible-light photocatalytic conjugate addition to prepare 1,4-dicarbonyl compounds has been developed by employing readily available aroyl chlorides as aryl radical sources. This operationally simple method shows a broad scope with regard to both aroyl chlorides and Michael acceptors. As a result, a variety of 1,4-diketones were efficiently synthesized in moderate to good yields.

THERAPEUTIC AGENT FOR DIABETES

A therapeutic agent for diabetes, which comprises a compound of the formula [I] wherein Xis a group of the formula wherein R4and R5are the same or different and each is a hydrogen atom, an optionally substituted alkyl having 1 to 5 carbon atoms and the like, and R6is a hydrogen atom or an amino-protecting group; R1is an optionally substituted alkyl having 1 to 5 carbon atoms, an optionally substituted alkenyl having 2 to 6 carbon atoms and the like, R2is a hydrogen atom, an optionally substituted alkyl having 1 to 5 carbon atoms and the like, R2' is a hydrogen atom, and R3is an optionally substituted alkyl having 1 to 5 carbon atoms and the like, a prodrug thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof and a solvate thereof. The compound of the present invention shows superior blood sugar decreasing action on the state of hyperglycemia, but does not affect the blood sugar when it is in the normal range or in the hypoglycemic state, which means that it is free of serious side effects such as hypoglycemia. Therefore, the compound of the present invention is useful as a therapeutic drug for diabetes and also useful as a preventive of the chronic complications of diabetes.