925436-46-0

Basic information

• Product Name: 4-[[6-[2-[(2-QUINOXALINYLCARBONYL)AMINO]PHENYL]IMIDAZO [2,1-B]THIAZOL-3-YL]METHYL]-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
• Synonyms: tert-Butyl 4-((6-(2-(quinoxaline-2-carboxamido)phenyl)imidazo-[2,1-b]thiazol-3-yl)methyl)piper;4-[[6-[2-[(2-QUINOXALINYLCARBONYL)AMINO]PHENYL]IMIDAZO [2,1-B]THIAZOL-3-YL]METHYL]-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER;1-Boc-4-[[6-[2-[(2-quinoxalinylcarbonyl)aMino]phenyl]iMidazo[2,1-b]thiazol-3-yl]Methyl]piperazine;tert-Butyl 4-((6-(2-(quinoxaline-2-carboxamido)phenyl)imidazo-[2,1-b]thiazol-3-yl)methyl)piperazi;tert-Butyl 4-((6-(2-(quinoxaline-2-carboxamido)phenyl)imidazo-[2,1-b]thiazol-3-yl)methyl)piperazine-1-carboxylate
• CAS NO: 925436-46-0
• Molecular Formula: C30H31N7O3S
• Molecular Weight: 569.67724
• Mol File: 925436-46-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.37±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 11.19±0.70(Predicted)
• CAS DataBase Reference: 4-[[6-[2-[(2-QUINOXALINYLCARBONYL)AMINO]PHENYL]IMIDAZO [2,1-B]THIAZOL-3-YL]METHYL]-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[[6-[2-[(2-QUINOXALINYLCARBONYL)AMINO]PHENYL]IMIDAZO [2,1-B]THIAZOL-3-YL]METHYL]-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER(925436-46-0)
• EPA Substance Registry System: 4-[[6-[2-[(2-QUINOXALINYLCARBONYL)AMINO]PHENYL]IMIDAZO [2,1-B]THIAZOL-3-YL]METHYL]-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER(925436-46-0)

Safety Data

• Hazardous Substances Data: 925436-46-0(Hazardous Substances Data)

Usage

General Description

"4-[[6-[2-[(2-quinoxalinylcarbonyl)amino]phenyl]imidazo[2,1-b]thiazol-3-yl]methyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester" is a chemical compound with a complex molecular structure. It contains a piperazinecarboxylic acid group, a quinoxalinylcarbonyl amino group, and an imidazo-thiazol-3-ylmethyl group, all connected to a 1,1-dimethylethyl ester functional group. 4-[[6-[2-[(2-QUINOXALINYLCARBONYL)AMINO]PHENYL]IMIDAZO [2,1-B]THIAZOL-3-YL]METHYL]-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER may have a variety of potential applications in fields such as medicinal chemistry and pharmaceuticals due to the presence of these functional groups, which can influence its biological activity and pharmacokinetic properties. Additional research and testing would be necessary to fully understand the potential uses and effects of this compound.

Upstream product

• 54745-92-5 quinoxaline-2-carboxylic acid chloride 
• 925437-87-2 4-[6-(2-aminophenyl)imidazo[2,1-b]thiazol-3-ylmethyl]piperazine-1-carboxylic acid tert-butyl ester 
• 925437-85-0 (6-(2-nitrophenyl)imidazo[2,1-b]thiazol-3-yl)methanol 
• 925437-84-9 6-(2-nitrophenyl)-imidazo[2,1-b]thiazole-3-carboxylic acid ethyl ester 
• 912770-13-9 6-(2-nitro-phenyl)-imidazo[2,1-b]thiazole-3-carboxylic acid 
• 1093403-37-2 C₁₃H₁₁N₃O₅S₂ 
• 6851-99-6 2-bromo-1-(2-nitrophenyl)ethanone 

Downstream Products

• 925434-55-5 SRT1720 

Relevant articles and documents

Discovery of imidazo[1,2-6]thiazole derivatives as novel SIRT1 activators

A series of imidazo[1,2-b]thiazole derivatives is shown to activate the NAD+-dependent deacetylase SIRT1, a potential new therapeutic target to treat various metabolic disorders. This series of compounds was derived from a high throughput scree

SIRTUIN POLYMORPHISMS AND METHODS OF USE THEREOF

Provided herein are methods for diagnosis and prognosis using polymorphic variants of sirtuins. Such polymorphic may be used, for example, to identify subjects that would be responsive to treatment with a sirtuin modulating compound andor subjects that are suffering from or susceptible to a disease mediated by a sirtuin. Also provided are methods for determining the predictive value of a sirtuin polymorphic variant, methods for evaluating sirtuin modulating compounds, and methods for determining appropriate dosage andor treatment regimens for subjects having one or more sirtuin polymorphic variants. Screening methods for identifying sirtuin modulating compounds using polymorphic variants of a sirtuin are also provided.