92545-30-7Relevant articles and documents
Synthesis and biological evaluation of 2-alkyl-2-methoxymethyl-salvinorin ethers as selective κ-opioid receptor agonists
Lee, David Y.W.,Deng, Gang,Ma, Zhongze,Xu, Wei,Yang, Lu,Liu, Jing,Dai, Ronghua,Liu-Chen, Lee-Yuan
, p. 4689 - 4692 (2015)
The synthesis of a new series of C-2-alkyl-2-methoxymethyl-salvinorin ethers and their binding affinities at κ-, μ-, and δ-opioid receptors are presented. We have developed a synthesis that enables installation of alkyl-substituents at C-2 while maintaining the integrity of the C-2 methoxymethyl ether and retaining κ-opioid receptor binding activity. Among these new compounds, 2-methyl-2-methoxymethyl-salvinorin ether (9a) is a potent full agonist at the κ receptor and shows comparable potency in Ki and EC50 with salvinorin A and U50488H. These C2-alkylated analogs have been identified as full κ agonists.
Salvinorin immunoassay
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Page/Page column 8, (2016/02/03)
The present invention provides an immunoassay method for detecting or determining the amount of salvinorin A, salvinorin B and/or analogues thereof in an in vitro sample, an antibody for salvinorin A, salvinorin B and/or analogues thereof and a kit for detecting the presence of or determining the amount of salvinorin A, salvinorin B and its analogues thereof in a sample.
Asymmetric synthesis of salvinorin A, a potent κ opioid receptor agonist
Scheerer, Jonathan R.,Lawrence, Jonathan F.,Wang, Grace C.,Evans, David A.
, p. 8968 - 8969 (2008/02/12)
The stereoselective synthesis of salvinorin A is described. A macrocyclic bis-Michael reaction cascade provides the requisite tricyclic skeleton as a single diastereomer. Copyright