92614-59-0 Usage
Description
Glutathione Ethyl Ester is a cell-permeable derivative of Glutathione (GSH), a vital molecule involved in detoxification and reduction of hydroperoxides. It serves as a nucleophilic co-substrate to glutathione transferase and is an essential electron donor to glutathione peroxidases. Glutathione Ethyl Ester undergoes hydrolysis by intracellular esterases to release GSH, allowing for effective transport and protection of cells against damage from radiation, oxidants, and various toxic compounds, including heavy metals.
Uses
Used in Biomedical Applications:
Glutathione Ethyl Ester is used as a cell protectant for enhancing the resilience of cells against damage from radiation, oxidants, and toxic compounds such as heavy metals. Its effective transport and subsequent release of GSH within cells provide a valuable means of safeguarding cellular integrity and function.
Used in Cellular Research:
Glutathione Ethyl Ester is used as a tool to increase intracellular glutathione levels in various cell types, such as mouse fibroblast L929 cells. This application aids researchers in studying the effects of elevated GSH levels on cellular processes and responses to different stimuli.
Used in Medium Supplementation:
In the context of cell culture, Glutathione Ethyl Ester is used as a medium supplement in Spodoptera frugiperda (Sf)9 cells. This application helps evaluate the effects of GSH ethyl ester on lipid peroxidation and other cellular responses, particularly in the aftermath of events like spinal cord injury.
Used in Pharmaceutical Development:
Given its role in detoxification and protection against various harmful agents, Glutathione Ethyl Ester holds potential in the development of pharmaceuticals aimed at treating conditions associated with oxidative stress, radiation damage, and exposure to toxic substances. Its cell-permeable nature makes it a promising candidate for drug delivery systems designed to enhance the therapeutic effects of GSH.
Biochem/physiol Actions
Glutathione reduced ethyl ester (GSH-MEE) is a membrane/lipid permeable derivative of GSH that may be used to partially supplement the GSH supply within cells subjected to cysteine and/or GSH depletion. GSH-MEE is hydrolysed by intracellular esterases to release GSH, thereby increases the concentrations of intracellular GSH. It prevents the toxic effects of acetaminophen in animal cells. It protects human lymphoid cells and skin fibroblasts against the damage caused due to radiation.
Check Digit Verification of cas no
The CAS Registry Mumber 92614-59-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,6,1 and 4 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 92614-59:
(7*9)+(6*2)+(5*6)+(4*1)+(3*4)+(2*5)+(1*9)=140
140 % 10 = 0
So 92614-59-0 is a valid CAS Registry Number.
InChI:InChI=1/C12H21N3O6S/c1-2-7(22)10(11(19)14-5-9(17)18)15-8(16)4-3-6(13)12(20)21/h6-7,10,22H,2-5,13H2,1H3,(H,14,19)(H,15,16)(H,17,18)(H,20,21)/t6-,7?,10-/m0/s1
