92632-81-0

Basic information

• Product Name: 5-phthaliMidolevulinic acid
• Synonyms: 5-phthaliMidolevulinic acid;5-(1,3-Dioxoisoindolin-2-yl)-4-oxopentanoic acid
• CAS NO: 92632-81-0
• Molecular Formula: C₁₃H₁₁NO₅
• Molecular Weight: 261.23014
• EINECS: -0
• Mol File: 92632-81-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), DMSO (Slightly)
• CAS DataBase Reference: 5-phthaliMidolevulinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-phthaliMidolevulinic acid(92632-81-0)
• EPA Substance Registry System: 5-phthaliMidolevulinic acid(92632-81-0)

Safety Data

• Hazardous Substances Data: 92632-81-0(Hazardous Substances Data)

Usage

Uses

5-Phthalimidolevulinic Acid is a related compound of 5-aminolevulinic acid; used as an add-on agent for photodynamic therapy.

Upstream product

• 6284-26-0 2-(3-bromo-2-oxopropyl)-1H-isoindole-1,3 (2H)-dione 
• 16493-28-0 N-(2,5-dimethoxy-2,5-dihydro-furan-2-ylmethyl)-phthalimide 
• 58960-19-3 2-{[5-oxotetrahydrofuran-2-yl]methyl}-1H-isoindole-1,3(2H)-dione 
• 26116-10-9 2-((tetrahydrofuran-2-yl)methyl)isoindoline-1,3-dione 
• 4795-29-3 TETRAHYDROFURFURYLAMINE 
• 85-44-9 phthalic anhydride 
• 64272-85-1 5-phthalimidolevulinaldehyde 
• 63458-74-2 2-phthalimidomethyl-2,5-dimethoxytetrahydrofuran 
• 1623-88-7 5-chloromethylfurfural 
• 116750-06-2 5-(1,3-dioxo-2,3-dihydro-1H-2-isoindolylmethyl)-2-furaldehyde 
• 617-89-0 furan-2-ylmethanamine 
• 16493-29-1 4-oxo-5-phthalimido-pent-2-enoic acid 
• 4667-83-8 2-(furan-2-ylmethyl)isoindoline-1,3-dione 
• 1074-82-4 potassium phtalimide 

Downstream Products

• 4708-67-2 3-(2-thioxo-2,3-dihydro-1H-imidazol-4-yl)-propionic acid 
• 5451-09-2 5-aminolevulinic acid hydrochloride 
• 92632-82-1 3-chlorobenzoyl 5-phthalimidolevulinoyl peroxide 
• 106-60-5 ALA 
• 65706-98-1 ethyl 5-(1,3-dioxoisoindolin-2-yl)-4-oxopentanoate 
• 92632-83-2 4-(3-chlorobenzoyloxy)-1-phthalimidobutan-2-one 

Relevant articles and documents

Preparation method of 5 -aminolevulinic acid hydrochloride intermediate (by machine translation)

The invention relates to a preparation method of 5 -aminolevulinic acid hydrochloride intermediate, which belongs to the field of pharmaceutical compound synthesis and provides a 5 -aminolevulinic acid hydrochloride intermediate preparation method which comprises the following technical points: (a), (1) or (2) compound in reaction solvent a, oxidizing agent a, compound of formula (5); or process b) wherein the compound of formula (6) or formula (3 4) is obtained under the action of a reaction solvent b and an oxidizing agent b 6. The compound of formula (6) is then purified to give 5 -aminolevulinic acid hydrochloride by an acidic hydrolysis deprotecting group, or a direct acidic hydrolysis deprotecting group. The environment-friendly oxidation reagent is adopted, the quality requirement of high-quality medicine raw materials can be met at the same time, the production efficiency can be improved, and the requirement of industrial large-scale production can be met. (by machine translation)

Process for preparing 5-aminolevulinic acid from 5-chloromethyl furfural

The invention discloses a process for preparing 5-aminolevulinic acid from 5-chloromethylfurfural. The biomass-based 5-chloromethylfurfural and cheap and easily available potassium phthalimide are used as reaction raw materials to react to obtain ammoniated product 5-(phthalimide) methylfurfural with a yield of 97.1%, and then the 5-ALA is obtained through synthesis steps of photooxidation, reduction, hydrolysis and the like. The structure of the 5-ALA is determined by nuclear magnetic resonance. The purity of the 5-ALA is 96.1% and the total reaction yield is 23.7%. Compared with the traditional chemical synthesis route of the 5-aminolevulinic acid, the process has the advantages of cheap and easily available raw materials, simple and convenient operation, mild reaction conditions, no toxicity and the like, and has a good industrial popularization prospect.

Process for preparing 5-aminolevulinic acid

A process for preparing 5-aminolevulinic acid or a salt thereof, which comprises reacting furfurylamine, of which the amino group has been protected, with oxygen molecule under irradiation by light in the presence of a sensitizer; hydrogenating the resulting compound in the presence of a metallic catalyst; and hydrolyzing the hydrogenated compound. 5-Aminolevulinic acid, useful as a raw material for various chemicals and as an agricultural chemical, can be prepared at a high yield by a simple procedure from a raw material which is inexpensive and readily available.